Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020
The Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report provides comprehensive understanding and unprecedented access to the discovery stage partnering agreements entered into by the worlds leading biopharma companies.
The Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report.
The report provides a detailed understanding and analysis of how, why and on what terms companies enter discovery stage partnering deals. These deals are discovery stage whereby the licensee obtains a right or an option right to license the licensors product or technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes.
This report provides details of the latest discovery agreements announced in the healthcare sector.
Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases and databases do not.
This report contains a comprehensive listing of all discovery stage partnering deals announced since 2014 including financial terms where available including over 2,500 links to online deal records of actual discovery partnering deals as disclosed by the deal parties. In addition, where available, records include contract documents as submitted to the Securities Exchange Commission by companies and their partners.
Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.
The initial chapters of this report provide an orientation of discovery stage deal making and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an overview of why companies partner discovery stage compounds/products.
Chapter 3 provides an overview of discovery stage deals strategy and deal structure including numerous case studies. Chapter 4 provides an overview of the various payment strategies used in discovery stage deals.
Chapter 5 provides a review of discovery stage deal making since 2014. Deals activity is reviewed by year, therapeutic area, technology type, as well as most active dealmakers.
Chapter 6 provides a detailed analysis of discovery stage payment terms including headline, upfront, milestone and royalty rates.
Chapter 7 provides a review of the leading discovery stage deal by headline value. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand.
Chapter 8 provides a comprehensive listing of the top 25 most active discovery stage dealmaker companies. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand.
Chapter 9 provides a comprehensive and detailed review of discovery stage partnering deals signed and announced since 2014, where a contract document is available in the public domain.
Chapter 10 provides a comprehensive directory of discovery stage partnering deals since 2014.
The report includes deals announced by hundreds of life science companies including big pharma such as Abbott, Abbvie, Actavis, Amgen, Astellas, AstraZeneca, Baxter, Bayer, Biogen Idec, BMS, Celgene, Eisai, Eli Lilly, Gilead, GSK, J&J, Kyowa Hakko, Merck, Mitsubishi, Mylan, Novartis, Pfizer, Roche, Sanofi, Shire, Takeda, Teva, and Valeant, amongst many others.
The report also includes numerous tables and figures that illustrate the trends and activities in discovery stage partnering and deal making since 2014.
In addition, a comprehensive appendix of all discovery deals since 2014 is provided organized by partnering company A-Z, deal type, therapy focus and technology type. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of discovery stage products and compounds.
Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 provide the reader with the following key benefits:
- In-depth understanding of discovery stage deal trends since 2014
- Access to headline, upfront, milestone and royalty data
- Analysis of the structure of discovery stage agreements with numerous real life case studies
- Insight into the terms included in a discovery stage agreement, together with real world clause examples
- Understand the key deal terms companies have agreed in previous deals
- Undertake due diligence to assess suitability of your proposed deal terms for partner companies
Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 is intended to provide the reader with an in-depth understanding and access to discovery stage deal trends and structure of deals entered into by leading companies worldwide.
Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 include:
- Trends in discovery stage dealmaking in the biopharma industry since 2014
- Analysis of discovery stage deal structure
- Access to headline, upfront, milestone and royalty data
- Case studies of real-life discovery stage deals
- Access to over 2,500 discovery stage deals
- The leading discovery stage deals by value since 2014
- Most active discovery stage dealmakers since 2014
- The leading discovery stage partnering 2014
In Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020, the available contracts are listed by:
- Company A-Z
- Headline value
- Stage of development at signing
- Deal type
- Specific therapy target
Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
The Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report provides comprehensive access to available deals and contract documents for over 2,500 discovery stage deals. Analyzing actual contract agreements allows assessment of the following:
- What are the precise rights granted or optioned?
- What is actually granted by the agreement to the partner company?
- What exclusivity is granted?
- What is the payment structure for the deal?
- How aresalesand payments audited?
- What is the deal term?
- How are the key terms of the agreement defined?
- How are IPRs handled and owned?
- Who is responsible for commercialization?
- Who is responsible for development, supply, and manufacture?
- How is confidentiality and publication managed?
- How are disputes to be resolved?
- Under what conditions can the deal be terminated?
- What happens when there is a change of ownership?
- What sublicensing and subcontracting provisions have been agreed?
- Which boilerplate clauses does the company insist upon?
- Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
- Which jurisdiction does the company insist upon for agreement law?
Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report provides the reader with the following key benefits:
- In-depth understanding of discovery stage deal trends since 2014
- Access to headline, upfront, milestone and royalty data
- Comprehensive access to over 2,500 discovery stage deals together with contract documents if available
- Detailed access to actual discovery stage deals entered into by the leading fifty big pharma and big biotech companies along with other biopharma companies
- Analysis of the structure of discovery stage agreements with numerous real life case studies
- Identify leading discovery stage deals by value since 2014
- Identify the most active discovery stage dealmakers since 2014
- Full listing of discovery stage deals by company A-Z, phase of development, deal type, therapy and technology focus
- Understand the key deal terms companies have agreed in previous deals
- Undertake due diligence to assess suitability of your proposed deal terms for partner companies
Chapter 1 – Introduction
Chapter 2 – Why do companies partner at discovery stage?
2.2. The role of discovery stage partnering
2.2.1. In-licensing at discovery stage
2.2.2. Out-licensing at discovery stage
2.3. Difference between discovery, preclinical and clinical stage deals
2.4. Reasons for entering into discovery stage partnering deals
2.4.1. Licensors reasons for entering discovery stage deals
2.4.2. Licensees reasons for entering discovery stage deals
2.5. The future of discovery stage partnering deals
Chapter 3 – Discovery stage deal strategies and structure
3.2. At what stage do companies partner?
3.2.1. Partnering early in pharmaceutical/biotech
184.108.40.206. Discovery and preclinical stage partnering case studies
220.127.116.11.a. Case study: LEO Pharma - 4SC
18.104.22.168.b. Case study: Heptares Therapeutics - Cubist
22.214.171.124.c. Case study: Incyte – Agenus Bio
126.96.36.199.d. Case study: Janssen Pharmaceutical - Evotec
3.2.2. Partnering later in pharmaceutical/biotech
188.8.131.52. Clinical stage partnering case studies
184.108.40.206.a. Case study: Servier – GeNeuro
220.127.116.11.b. Case study: Teva – Xenon Pharmaceuticals
18.104.22.168.c. Case study: AstraZeneca - Ardelyx
22.214.171.124.d. Case study: Baxter – Onconova Therapeutics
3.3. Early and later stage partnering – a risk/cost comparison
3.4. What do companies spend on discovery, preclinical and clinical stage partnering?
3.5. Pure versus multi-component partnering deals
3.6. Pure licensing agreement structure
3.6.1. Example pure licensing agreements
3.6.1.a. Case study : Pfizer – Spark Therapeutics
3.6.1.b. Case study : Contrafect – Trellis Bioscience
3.7. Multicomponent discovery stage partnering agreements
3.7.1.a. Example multicomponent early stage clauses
3.7.1.a. Case study: Tracon – Boehringer Ingelheim – Macrogenics
3.7.1.b. Case study: Fibrocell Science – Intrexon
Chapter 4 – Discovery stage partnering payment strategies
4.2. Discovery stage payment strategies
4.3. Payment options
4.3.1. Headline values
4.3.2. Upfront payments
126.96.36.199. Conditionality of upfront payments
4.3.4. Convertible loans
4.3.6. R&D funding
4.3.7. Licensing fees
4.3.8. Milestone payments
4.3.9. Royalty payments
188.8.131.52. Issues affecting royalty rates
184.108.40.206. Royalties on combination products
220.127.116.11.a. Case study: Scripps Research Institute-Cyanotech
18.104.22.168. Guaranteed minimum/maximum annual payments
22.214.171.124. Royalty stacking
126.96.36.199. Royalties and supply/purchase contracts
4.3.11. Option payments
Chapter 5 – Trends in discovery stage deal making
5.2. Discovery stage partnering over the years
5.2.1. Attributes of discovery deals
5.3. Discovery stage partnering by deal type
5.4. Discovery stage partnering by disease type
5.5. Partnering by discovery stage technology type
5.6. Discovery stage partnering by most active company since 2014
Chapter 6 – Payment terms for discovery stage partnering
6.2. Guidelines for discovery stage payment terms
6.2.1. Upfront payments
6.2.2. Milestone payments
6.2.3. Royalty payments
6.3. Discovery stage payment terms – deal data analysis
6.3.1. Public data
6.3.2. Survey data
6.4. Payment terms analysis
6.4.1. Discovery stage headline values
6.4.2. Discovery stage deal upfront payments
6.4.3. Discovery stage deal milestone payments
6.4.4. Discovery stage royalty rates
Chapter 7 – Leading discovery stage deals
7.2. Top discovery stage deals by value
Chapter 8 – Top 25 most active discovery stage dealmakers
8.2. Top 25 most active discovery stage dealmakers
Chapter 9 – Discovery stage partnering contracts directory
9.2. Discovery stage deals with contracts 2014 to 2020
Chapter 10 – Discovery stage deal making by development stage
10.2. Deals by discovery stage
Appendix 1 – Discovery stage dealmaking by companies A-Z
Appendix 2 – Discovery stage dealmaking by industry sector
Appendix 3 – Discovery stage dealmaking by stage of development
Appendix 4 – Discovery stage dealmaking by therapy area
Appendix 5 – Discovery stage dealmaking by technology type
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Table of figures
Figure 1: Definition of discovery, preclinical and clinical phases in dealmaking
Figure 2: Components of the pure licensing deal structure
Figure 3: Payment options for discovery stage partnering deals
Figure 4: Issues affecting royalty rates
Figure 5: Discovery stage partnering frequency 2014- 2020
Figure 6: Discovery stage partnering by deal type since 2014
Figure 7: Discovery stage partnering by disease type since 2014
Figure 8: Discovery stage partnering by technology type since 2014
Figure 9: Top 25 most active discovery stage dealmakers, 2014 to 2020
Figure 10: Review of median upfront payments for discovery stage deals
Figure 11: Review of median milestone payments for discovery stage deals
Figure 12: Review of median royalty payments for discovery stage deals
Figure 13: Discovery stage deals with a headline value
Figure 14: Discovery stage deals with an upfront value
Figure 15: Discovery stage deals with a milestone value
Figure 16: Discovery stage deals with a royalty rate value
Figure 17: Top discovery stage deals that exceeds $1 billion in deal value since 2014
Figure 18: Most active discovery stage dealmakers 2014 to 2020
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1CellBiO, 1ST Biotherapeutics, 2A, 3B Pharmaceuticals, 3SBio, 4D Molecular Therapeutics, 4D Pharma, 10X Genomics, 14M Genomics, 22nd Century, 23andMe, 48Hour Discovery, A*STAR Agency for Science, Technology and Research, A*STAR Genome Institute of Singapore, A*STAR’ Institute of Molecular and Cell Biology, A-Alpha Bio, A.I. Squared, A1M Pharma, A2A Pharmaceuticals, Abbvie, Abby Grace Foundation, Abcam, AbCellera, AbCheck, Abcuro, Abeona Therapeutics, Abide Therapeutics, Abilita Bio, Ab Initio, ABL Bio, Ablexis, Ablynx, AbMed, Abpro, Abramson Cancer Center, Abveris, Abzena, Academic Drug Discovery Consortium, Acceleron Pharma, Accelovance, Accenture, ACEA Biosciences, Acerta Pharma, Acetylon Pharmaceuticals, AC Immune, Actavis (name changed to Allergan), Actelion, Actinium Pharmaceuticals, ActoGeniX, AcuraStem, Adagene, AdAlta, Adapsyn Bioscience, Adaptate Biotherapeutics, Adaptimmune, Adaptive Biotechnologies, Adaptive Phage Therapeutics, ADC Therapeutics, Adimab, AdoRx Therapeutics, ADT Pharmaceuticals, Aduro BioTech, Advaita, Advaite, Advanced Biological Laboratories, Advanced Proteome Therapeutics, Advaxis, Adverum Biotechnologies, Adynxx, Aelan Cell Technologies, Aeras, AEterna Zentaris, Aetion, Aevi Genomic Medicine, Aevitas Therapeutics, Affibody, Affimed Therapeutics, Affinivax, AFFiRiS, Affymetrix, AffyXell Therapeutics, Afraxis, AgBiome, Age Labs, Agendia, Agensys, Agenus Bio, AgeX Therapeutics, Agilent Technologies, Agilis Biotherapeutics, AgomAb Therapeutics, AgonOx, AGTC, AiCuris, AiVita Biomedical, AKESOgen, Akili Interactive Labs, Akouos, Akoya Biosciences, Akrevia Therapeutics, Akriveia Therapeutics, Albert Einstein College of Medicine, Albumedix, Alderley Analytical, Aldevron, Aldeyra Therapeutics, Alector, Alexion Pharmaceuticals, Algenex, AliHealth, AlivaMab Discovery Services, Alize Pharma, ALK-Abello, Alkahest, Alkermes, Allakos, Allele Biotechnology and Pharmaceuticals, Allen Institute for Brain Science, Allergan, Allied-Bristol Life Sciences, Alligator Bioscience, Allogene Therapeutics, Almac Discovery, Almac Group, Almirall, Alnylam Pharmaceuticals, Alpine Immune Sciences, ALS Association, ALS Biopharma, Altasciences, Alteogen, Alytas Therapeutics, Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Alzheimer's Foundation of America, Alzheimer's Research UK, Alzheimer Society Research, Alzheimers Research UK, Amarantus BioSciences, Amarna Therapeutics, Amazon Web Services, Ambrx, Ambys Medicines, American Academy of Ophthalmology, American Association for Cancer Research, American BriVision, American Cancer Society, American Diabetes Association, American Lung Association, American National Multiple Sclerosis Society, American Skin Association, American Society of Clinical Oncology (ASCO), American Society of Hematology, Amfora, Amgen, Amicus Therapeutics, AmorChem, AmpliPhi Biosciences, AMR, AMRA, Amunix, Amyris, AnaBios, Anaeropharma, Analysis Group, Analytical Biological Services, Analytics Engines, AnaMar, ANANDA Scientific, Anandia Laboratories, Anchiano Therapeutics, AnGes MG, Angle, Anika Therapeutics, Anima Biotech, Anji Pharma, Annette Funicello Research Fund for Neurological Diseases (AFRFND), Annoroad, ANP Technologies, Antengene, Anterios, Anthem, Antibody Solutions, Antikor Biopharma, Antitope, Apeiron Biologics, Aphios, Applied BioMath, APRINOIA Therapeutics, Aptahem, Aptamer Therapeutics, Aptose Biosciences, Aptuit, Aqilion, Aquinnah Pharmaceuticals, Arbele, Arbor Biotechnologies, Arbutus, Arcadia Biosciences, Arcturus Therapeutics, Ardelyx, Ardent Mills, Arena Pharmaceuticals, Ares Genetics, Ares Life Sciences, arGEN-X, argenx, Argos Therapeutics, Ariad Pharmaceuticals, Ariana Pharma, Aridis Pharmaceuticals, Arisaph Pharmaceuticals, Arix Bioscience, Ark Biosciences, ARMO Biosciences, Aro Biotherapeutics, Arpeggio Biosciences, Arrakis Therapeutics, Array Biopharma, Arrevus, Arrow Pharmaceuticals, Artelo Biosciences, Artes Biotechnology, Artialis, Artios Pharma, Artizan Biosciences, Arvinas, Arzeda, Asahi Kasei, Asana Biosciences, Asceneuron, Ascenion, ASKA Pharmaceuticals, Asklepios Biopharmaceutical, Aspira Scientific, Aspyrian Therapeutics, Astellas Pharma, Astex Pharmaceuticals, Asthma UK, AstraZeneca, Atara Biotherapeutics, Ataxion, aTen Therapeutics, Athenex, Atomwise, Atossa Genetics, Atrapos Therapeutics, Atreca, Atropos Therapeutics, ATUM, Atvio Biotech, aTyr Pharma, Auburn University, Audentes Therapeutics, Audion Therapeutics, AUM Biotech, Aural Analytics, Aurigene Discovery Technologies, Auris Medical, Auron Therapeutics, Australian Department of Health and Ageing, Australian Foundation for Diabetes Research, Australian Research Council, Autifony Therapeutics, Autodesk, Autolus, Avacta, Avactis Biosciences, Avalon GloboCare, AvantGen, Avidity Biosciences, Avidity NanoMedicines, Avita Medical, Axcelead Drug Discovery Partners, Axcella, Axiogenesis, AxioMx, Axis Therapeutics, Axovant Sciences, Axxam, AyoxxA Biosystems, AzurRx BioPharma, B-MoGen Biotechnologies, Babraham Institute, Bacit, Bactevo, Barbara Ann Karmanos Cancer Institute, Baruch S Blumberg Institute, BASF, Basilea Pharmaceutica, Batavia Biosciences, Battelle, Baudry Laboratory, Bavarian Nordic, Baxalta, Baxter International, Bayer, Bayer Healthcare, Baylor College, Baylor College of Medicine, Baylor Institute for Immunology Research, Baylor Miraca Genetics Laboratories, BCD Bioscience, BD Biosciences, Beacon Discovery, Beactica, Beam Therapeutics, BeiGene, Bellerophon Therapeutics, Bellicum Pharmaceuticals, Ben-Gurion University, Benchwise, BenevolentAI, Benitec Biopharma, Berg, Berkeley Lights, Beroni Group, Bertin Pharma, Beta Therapeutics, Be The Match BioTherapies, Beth Israel Deaconess Medical Center, Beyond Batten Disease Foundation, BGN Technologies, Biametrics, Bicycle Therapeutics, Bill and Melinda Gates Foundation, BIND Therapeutics, Bio-Cancer Treatment International, Bio-Rad Laboratories, Bio-Techne, BioArctic Neuroscience, biOasis Technologies, BIOASTER, BioAtla, BioBlast Pharma, Bioblock, BioBright, Biocept, BioCision, Biocodex Microbiota Foundation, BioCurate, Biodextris, BioFluidica, Biofourmis, Biogen, Biognosys, Biohaven Pharmaceutical Holding, BioInvent, BioIVT, BioLegend, BiolineRX, Biolin Scientific, BioLite Japan, Biomed Elements, Biomedical Advanced Research and Development Authority, Biomedical Catalyst Fund (UK), BioMed Realty Trust, BioMed X Innovation Center, bioMerieux, Biomica, Biomillenia, BioMotiv, Biomunex Pharmaceuticals, BiomX, BioNano Genomics, Bioneer, Bionetix, Bioniz Therapeutics, BioNovion, BioNTech, BionX Medical Technologies, Bioo Scientific, Bio Palette, BioPontis Alliance, BioReference Laboratories, Biorelate, BioReliance, BioRestorative Therapies, Biosceptre International, Biosearch Technologies, BioSolveIT, Biostar Pharmaceuticals, Biotechnology and Biological Sciences Research Council (BBSRC), Biotem, Biothera, Biotheus, BioVaxys, Bioverativ, BioVersys, BioXcel, Bioz, BirchBioMed, Bird Foundation, Bit Bio, Blackfynn, BlackThorn Therapeutics, BlinkBio, BliNK Biomedical, Bliss Biopharmaceutical, Blockchain Global, Bloom Burton, Bloom Science, Bluebird Bio, Blue Buffalo Company, Blue Cross Blue Shield Association, Bluefield Innovations, Blueprint Medicines, BlueRock Therapeutics, Blue Water Vaccines, Boehringer Ingelheim, Boehringer Ingelheim Vetmedica, Bonbouton, Bone Therapeutics, Bonnie J. Addario Lung Cancer Foundation, Boragen, Boston Biomedical, BostonGene, Boston University, Boston University School of Medicine, Botanisol, Boulos and Cooper Pharmaceuticals, Bpifrance, Brain & Behavior Research Foundation, Brain Biomarker Solutions in Gothenburg, Brain Science Foundation, BravoVax, BRCA Foundation, Breath Diagnostics, BrickBio, Brickell Biotech, BridgeBio Pharma, Brigham and Women's Hospital, BrightFocus Foundation, Brighton Biotech, Brii Biosciences, BRIM Biotechnology, Bristol-Myers Squibb, British Pharmacological Society, Broad Institute, Brown University, Buck Institute for Age Research, BullFrog AI, Burnet Institute, C2N Diagnostics, C4 Therapeutics, C4X Discovery, Caerus Discovery, Caladrius Biosciences, Calico, California Institute for Biomedical Research, California Institute for Quantitative Biosciences (QB3), California Institute for Regenerative Medicine, California Institute of Technology, Calimmune, Calithera Biosciences, Calixar, Calyxt, Cambridge Enterprise, Camino Pharma, CAMP4 Therapeutics, CANbridge Life Sciences, Cancer Australia, Cancer Immunotherapy Trials Network, Cancer Prevention and Research Institute of Texas, Cancer Research Institute, Cancer Research Technology, Cancer Research UK, Cantab Anti-infectives, Capnia, Capricor Therapeutics, CARB-X, Carbiotix, Cardiff University, Cardinal Partners, Cardurion Pharmaceuticals, Caribou Biosciences, Caris Life Sciences, Carmentix, Carmot Therapeutics, Carna BioSciences, Carnot BioSciences, Carolina BioOncology Institute, CARsgen, Cartana, Cartherics, Casebia Therapeutics, Case Western Reserve University, Casma Therapeutics, CasZyme, Catalan Institute of Nanotechnology (ICN), Catalent, Catholic University Leuven, CavoGene LifeSciences, CBT Pharmaceuticals, Cedars-Sinai Medical Center, CEITEC, Celgene, Cell2in, Celladon, Cellaria Biosciences, Cellecta, Cellectar Biosciences, Cellect Biotechnology, Cellectis, Cellesce, CELLINK, Cell Medica, Cell Mogrify, Cellthera Pharma, Cell Therapy Catapult, Celltrion, Cellular Biomedicine, Cellular Dynamics International, Cellular Research, Celmatix, Celonic, Celsius Therapeutics, Cenix BioScience, Centene, Center for Biomarker Research in Medicine, Center for Human Genetics and Laboratory Medicine, Center for Human Immunology, Autoimmunity and Inflammation, Center for Infectious Disease Research, Center for iPS Cells Research and Application, Centogene, Centre for Commercialization of Regenerative Medicine (CCRM), Centre for Drug Research and Development (CDRD), Centre For Proteomic & Genomic Research, Centre Hospitalier Régional Universitaire (CHRU) de Lille, Centre Hospital University - Bordeaux, Centre Leon Berard, Centre National de Biologie Expérimentale, Centre National de la Recherche Scientifique, Century Therapeutics, Cepheid, Cerevance, Certara, Cerveau Technologies, Ceva Sante Animale, Cevec Pharmaceuticals, Chan Zuckerberg Initiative, Chaperone Technologies, Charles River Laboratories, CHDI Foundation, Checkpoint Therapeutics, ChemDiv, ChemRar High-Tech Center, Chiesi Farmaceutici, Children's Heart Foundation, Children's Hospital Boston, Children's Hospital Los Angeles, Children's Hospital of Philadelphia, Children's Hospital Of Wisconsin, Children's Medical Research Institute, Children's National Health System, China-Singapore Guangzhou Knowledge City, China National Biotech Group (CNBG), China Southeast University, Chinese Academy of Agricultural Science, Chinese Academy of Sciences, Chiome Bioscience, Chiromics, Chongqing Lummy Pharma, Christian Doppler Research Association, Chronos Therapeutics, Chugai Pharmaceutical, Cidara Therapeutics, Cincinnati Children’s Hospital Medical Center, Cinda Bio-Pharmaceutical, Circuit Clinical, Circuit Therapeutics, Cisen Pharma, City of Hope, Civetta Therapeutics, Clalit Health Services, Clarity Pharmaceuticals, Cleara Biotech, Clearbridge Biomedics, ClearLight Diagnostics, ClearPath, Clene Nanomedicine, Cleveland Clinic, Cleveland HeartLab, Cleveland University Hospitals, Clevexel Pharma, Cloud Pharmaceuticals, Clover Therapeutics, Clovis Oncology, CNA Development, Co-Diagnostics, Coalition for Epidemic Preparedness Innovations, Cobra Biologics, Cocrystal Pharma, Codexis, Codiak BioSciences, COFCO Group, Cognition Therapeutics, Cohen Veterans Bioscience, Cold Spring Harbor, Collaborative Trajectory Analysis Project, Columbia University, Columbia University Medical Center, Complix, Compugen, Concept Life Sciences, Concerto HealthAI, Confo Therapeutics, Congenica, Conkwest, Connecticut Children’s Medical Center, ConsortiaTX, Consortium AI, Context Therapeutics, Contextual Genomics, ContraFect, ContraVir Pharmaceuticals, Convelo Therapeutics, Cooperative Research Centre for Cell Therapy Manufacturing, Cord Blood Registry, CoreBiome, Corestem, Cornell University, Coronado Biosciences, Corporation for Biological Research, Corteva Agriscience, Cortexyme, Corvidia Therapeutics, COTA, COUR Pharmaceutical, Courtagen Life Sciences, Covalab, Covalent Data, Covaris, Create Vaccine Company, Creative Destruction Lab, Creative Medical Technologies, Crescendo Biologics, Cresset, Crestone Pharma, CRISPR Therapeutics, Cristal Therapeutics, Crohn's and Colitis Foundation of America, Crossbeta Biosciences, Crown Bioscience, Crystal Bioscience, CSL Behring, CTI BioPharma, Cue Biopharma, Cullinan Oncology, Cumberland Emerging Technologies, Cumberland Pharmaceuticals, Curable, Curadev Pharma, CureCell, Cure Duchenne, Cure Sanfilippo Foundation, Cure SMA, Cures Within Reach, Curetis, CureVac, Curie-Cancer, Curiox Biosystems, Curis, Cyclenium Pharma, Cyclica, Cyclotek, Cynata Therapeutics, Cypher Genomics, Cyrus Biotechnology, Cystic Fibrosis Foundation, Cystic Fibrosis Foundation Therapeutics, Cystinosis Research Foundation, CytoLumina Technologies, CytomX Therapeutics, Cytoo, CytoReason, CytoSen Therapeutics, Cytovant Sciences, CYTOVIA Therapeutics, Cytox, Daewoong Pharmaceutical, Daiichi Sankyo, Dainippon Sumitomo Pharma, Dalhousie University, Dana-Farber Cancer Institute, DarwinHealth, Datavant, David H. Koch Institute for Integrative Cancer Research, Da Volterra, DayTwo, Debiopharm, Decibel Therapeutics, deCODE Genetics, Deerfield Management, Defense Advanced Research Projects Agency, Defense Threat Reduction Agency, DefiniGEN, DeGregorio Family Foundation, Deinove, Dementia Consortium, Dementia Discovery Fund, Denali Therapeutics, Dendreon, DendroCyte, Department of Defense, Department of Economic development of Montgomery County, Department of Health and Human Services, Department of Veterans Affairs, DePuy, Dermala, Dermelix Biotherapeutics, Desktop Genetics, DestiNA Genomics, Devonian Health Group, Dewpoint Therapeutics, DiamiR, Diamond Light Source, Diatheva, DiCE Molecules, Dicerna Pharmaceuticals, Dimension Therapeutics, DiNAQOR, Disc Medicine, Distributed Bio, DNAnexus, DNA Script, DNAtrix, Dolomite Bio, Domainex, Domain Therapeutics, Dorian Therapeutics, Dow AgroSciences, Dr. Susan Love Research Foundation, Dragonfly Therapeutics, Dresner Foundation, Drugs for Neglected Diseases Initiative, Drukier Institute for Children's Health, Dualogics, Duke Clinical Research Institute (DCRI), Duke University, Dyadic International, DyNAbind, Dynamic Combinatorial Chemistry, DZNE German Center for Neurodegenerative Diseases, E-Scape Bio, E-Therapeutics, E.T. Horn, E3x Bio, Eagledream Health, Eagle Genomics, ECM Therapeutics, Ecole Polytechnique Federale de Lausanne, Edge Therapeutics, Edico Genome, EdiGene, Edison Nation Medical, Edison Pharmaceuticals, Editas Medicine, eFFECTOR Therapeutics, Eirion Therapeutics, Eisai, Eisai Inc, Elanco, Elasmogen, Elevian, Eli Lilly, Elixirgen, Ellison Medical Foundation, Elpis Biomed, Elpiscience, Elsevier, Elucidata, Embark Biotech, EMD Serono, Emendo Biotherapeutics, Emergence Therapeutics, Emergent BioSolutions, Emergex Vaccines, Emory University, Empirico, Enamine, EnBiotix, Encycle Therpaeutics, Endo Pharmaceuticals, Energesis Pharmaceuticals, enGene, Engineered Medical Solutions, Engitix, Enigma Biomedical, Enleofen Bio, Enlibrium, Enterome Bioscience, Enthera, Enumeral Biomedical, ENYO Pharma, EpiBiome, Epic Sciences, Epilepsy Society, Epivax, Epizyme, Erasmus University Medical Center, ERS Genomics, Ervaxx, ES Cell International, Escient Pharmaceuticals, Esophageal Cancer Awareness Association, 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