Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020
The Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 provides comprehensive understanding and unprecedented access to clinical stage partnering agreements entered into by the worlds leading biopharma companies
The Global Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014 - 2020 report provides a detailed understanding and analysis of how and why companies enter clinical stage partnering deals and provides details of the latest clinical agreements announced in the healthcare sector.
Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases and databases do not.
This report contains a comprehensive listing of over 2,000 clinical stage partnering deals announced since 2014 including financial terms where available including numerous links to online deal records of actual clinical partnering deals as disclosed by the deal parties. In addition, where available, records include contract documents as submitted to the Securities Exchange Commission by companies and their partners.
The initial chapters of this report provide an orientation of clinical stage deal making and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an overview of why companies partner clinical stage compounds/products.
Chapter 3 provides an overview of clinical stage deals strategy and deal structure including numerous case studies. Chapter 4 provides an overview of the various payment strategies used in clinical stage deals.
Chapter 5 provides a review of clinical stage deal making since 2014. Deals activity is reviewed by year, stage of development at signing, therapeutic area, technology type, as well as most active dealmakers.
Chapter 6 provides a detailed analysis of clinical stage payment terms including headline, upfront, milestone and royalty rates for phase I, phase II and phase III deals.
Chapter 7 provides a review of the leading clinical stage deal by headline value. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand.
Chapter 8 provides a comprehensive listing of the top 25 most active clinical stage dealmaker companies. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand.
Chapter 9 provides a comprehensive and detailed review of clinical stage partnering deals signed and announced since 2014, where a contract document is available in the public domain.
Chapter 10 provides a comprehensive directory of clinical stage partnering deals since 2014 organized by stage of development – phase I, phase II and phase III.
The report includes deals announced by hundreds of life science companies including big pharma such as Abbott, Abbvie, Actavis, Amgen, Astellas, AstraZeneca, Baxter, Bayer, Biogen Idec, BMS, Celgene, Eisai, Eli Lilly, Gilead, GSK, J&J, Kyowa Hakko, Merck, Mitsubishi, Mylan, Novartis, Pfizer, Roche, Sanofi, Shire, Takeda, Teva, and Valeant, amongst many others.
The report also includes numerous tables and figures that illustrate the trends and activities in clinical stage partnering and deal making since 2014.
In addition, a comprehensive appendix of all clinical stage deals since 2014 is provided organized by partnering company A-Z, deal type, therapy focus and technology type. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of clinical stage products and compounds.
Global Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014 - 2020 provides the reader with the following key benefits:
- In-depth understanding of clinical stage deal trends since 2014
- Access to headline, upfront, milestone and royalty data
- Analysis of the structure of clinical stage agreements with numerous real life case studies
- Insight into the terms included in a clinical stage agreement, together with real world clause examples
- Understand the key deal terms companies have agreed in previous deals
- Undertake due diligence to assess suitability of your proposed deal terms for partner companies
Global Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014- 2020 is intended to provide the reader with an in-depth understanding and access to clinical stage deal trends and structure of deals entered into by leading companies worldwide.
Global Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014- 2020 includes:
- Trends in clinical stage dealmaking in the biopharma industry since 2014
- Analysis of clinical stage deal structure
- Access to headline, upfront, milestone and royalty data
- Case studies of real-life clinical stage deals
- Access to over 2,000 clinical stage deals
- The leading clinical stage deals by value since 2014
- Most active clinical stage dealmakers since 2014
- The leading clinical stage partnering resources
In Global Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014- 2020, the available contracts are listed by:
- Company A-Z
- Headline value
- Stage of development at signing
- Deal type
- Specific therapy target
Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.
The Global Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014 - 2020 report provides comprehensive access to available deals and contract documents for over 2,000 clinical stage deals. Analyzing actual contract agreements allows assessment of the following:
- What are the precise rights granted or optioned?
- What is actually granted by the agreement to the partner company?
- What exclusivity is granted?
- What is the payment structure for the deal?
- How aresalesand payments audited?
- What is the deal term?
- How are the key terms of the agreement defined?
- How are IPRs handled and owned?
- Who is responsible for commercialization?
- Who is responsible for development, supply, and manufacture?
- How is confidentiality and publication managed?
- How are disputes to be resolved?
- Under what conditions can the deal be terminated?
- What happens when there is a change of ownership?
- What sublicensing and subcontracting provisions have been agreed?
- Which boilerplate clauses does the company insist upon?
- Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
- Which jurisdiction does the company insist upon for agreement law?
Clinical Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 provides the reader with the following key benefits:
- In-depth understanding of clinical stage deal trends since 2014
- Access to headline, upfront, milestone and royalty data
- Comprehensive access to over 2,000 clinical stage deals together with contract documents if available
- Detailed access to actual clinical stage deals entered into by the leading fifty big pharma and big biotech companies along with other biopharma companies
- Analysis of the structure of clinical stage agreements with numerous real life case studies
- Identify leading clinical stage deals by value since 2014
- Identify the most active clinical stage dealmakers since 2014
- Full listing of clinical stage deals by company A-Z, phase of development, deal type, therapy and technology focus
- Understand the key deal terms companies have agreed in previous deals
- Undertake due diligence to assess suitability of your proposed deal terms for partner companies
Chapter 1 – Introduction
Chapter 2 – Why do companies partner clinical stage compounds?
2.2. The role of clinical stage partnering
2.2.1. In-licensing at clinical stage
2.2.2. Out-licensing at clinical stage
2.3. Difference between phase I, II and III stage deals
2.4. Reasons for entering into clinical stage partnering deals
2.4.1. Licensors reasons for entering clinical stage deals
2.4.2. Licensees reasons for entering clinical stage deals
2.5. The future of clinical stage partnering deals
Chapter 3 – Clinical stage deal strategies and structure
3.2. At what stage do companies partner?
3.2.1. Partnering early in pharmaceutical/biotech
188.8.131.52. Discovery and preclinical stage partnering case studies
184.108.40.206.a. Case study: LEO Pharma - 4SC
220.127.116.11.b. Case study: Heptares Therapeutics - Cubist
18.104.22.168.c. Case study: Incyte – Agenus Bio
22.214.171.124.d. Case study: Janssen Pharmaceutical - Evotec
3.2.2. Partnering later in pharmaceutical/biotech
126.96.36.199. Clinical stage partnering case studies
188.8.131.52.a. Case study: Servier – GeNeuro
184.108.40.206.b. Case study: Teva – Xenon Pharmaceuticals
220.127.116.11.c. Case study: AstraZeneca - Ardelyx
18.104.22.168.d. Case study: Baxter – Onconova Therapeutics
3.3. Early and later stage partnering – a risk/cost comparison
3.4. What do companies spend on clinical stage partnering?
3.5. Pure versus multi-component partnering deals
3.6. Pure licensing agreement structure
3.6.1. Example pure licensing agreements
3.6.1.a. Case study : Argos Therapeutics – Medinet
3.6.1.b. Case study : Pfizer - GlycoMimetics
3.7. Multicomponent clinical stage partnering agreements
3.7.1. Example multicomponent clinical stage clauses
3.7.1.a. Case study: Gilead Sciences – GlobeImmune
Chapter 4 – Clinical stage partnering payment strategies
4.2. Clinical stage payment strategies
4.3. Payment options
4.3.1. Headline values
4.3.2. Upfront payments
22.214.171.124. Conditionality of upfront payments
4.3.4. Convertible loans
4.3.6. R&D funding
4.3.7. Licensing fees
4.3.8. Milestone payments
4.3.9. Royalty payments
126.96.36.199. Issues affecting royalty rates
188.8.131.52. Royalties on combination products
184.108.40.206.a. Case study: Scripps Research Institute-Cyanotech
220.127.116.11. Guaranteed minimum/maximum annual payments
18.104.22.168. Royalty stacking
22.214.171.124. Royalties and supply/purchase contracts
4.3.11. Option payments
Chapter 5 – Trends in clinical stage deal making
5.2. Clinical stage partnering over the years
5.2.1. Trends in phase I deals since 2014
126.96.36.199. Attributes of phase I deals
5.2.2. Trends in phase II deals since 2014
188.8.131.52. Attributes of phase II deals
5.2.3. Trends in phase III deals since 2014
184.108.40.206. Attributes of phase III deals
5.3. Clinical stage partnering by deal type
5.4. Clinical stage partnering by disease type
5.5. Partnering by clinical stage technology type
5.6. Clinical stage partnering by most active company since 2014
Chapter 6 – Payment terms for clinical stage partnering
6.2. Guidelines for clinical stage payment terms
6.2.1. Upfront payments
6.2.2. Milestone payments
6.2.3. Royalty payments
6.3. Clinical stage payment terms – deal data analysis
6.3.1. Public data
6.3.2. Survey data
6.4. Payment terms analysis
6.4.1. Clinical stage partnering headline values
6.4.2. Clinical stage deal upfront payments
6.4.3. Clinical stage deal milestone payments
6.4.4. Clinical stage royalty rates
6.5 Clinical stage median financials
6.5.1. Clinical stage headline value
6.5.2. Clinical stage upfront value
6.5.3. Clinical stage milestone value
6.5.4. Clinical stage royalty value
Chapter 7 – Leading clinical stage deals
7.2. Top clinical stage deals by value
Chapter 8 – Top 25 most active clinical stage dealmakers
8.2. Top 25 most active clinical stage dealmakers
Chapter 9 – Clinical stage partnering contracts directory
9.2. Clinical stage deals with contracts since 2014
Chapter 10 – Clinical stage deal making by development stage
10.2. Deals by clinical stage
Appendix 1 – Clinical stage dealmaking by companies A-Z
Appendix 2 – Clinical stage dealmaking by industry sector
Appendix 3 – Clinical stage dealmaking by stage of development
Appendix 4 – Clinical stage dealmaking by therapy area
Appendix 5 – Clinical stage dealmaking by technology type
About Wildwood Ventures
Recent report titles from Current Partnering
Table of figures
Figure 1: Definition of clinical phases in dealmaking
Figure 2: Components of the pure licensing deal structure
Figure 3: Payment options for clinical stage partnering deals
Figure 4: Issues affecting royalty rates
Figure 5: Phase I clinical stage partnering since 2014
Figure 6: Phase II clinical stage partnering since 2014
Figure 7: Phase III clinical stage partnering since 2014
Figure 8: Clinical stage partnering by deal type since 2014
Figure 9: Clinical stage partnering by disease type since 2014
Figure 10: Clinical stage partnering by technology type since 2014
Figure 11: Top 25 most active clinical stage dealmakers, 2014 to 2020
Figure 12: Review of upfront payments for clinical stage deals
Figure 13: Review of milestone payments for clinical stage deals
Figure 14: Review of royalty payments for clinical stage deals
Figure 15: Clinical stage deals with a headline value
Figure 16: Clinical stage deals with an upfront value
Figure 17: Clinical stage deals with a milestone value
Figure 18: Clinical stage deals with a royalty rate value
Figure 19: Summary median headline value by clinical stage of development, 2014-2020
Figure 20: Summary median upfront payments by clinical stage of development, 2014-2020
Figure 21: Summary median milestone payments by stage of development, 2014-2020
Figure 22: Summary median royalty rate by stage of development, 2014-2020
Figure 23: Top clinical stage deals by value since 2014
Figure 24: Most active clinical stage dealmakers 2014 to 2020
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2X Oncology, 3D Medicines, 3M Drug Delivery Systems, 3SBio, 4D Pharma, 4SC, AADi, Abbisko Therapeutics, Abbott Laboratories, Abbott Vascular Devices, Abbvie, Abide Therapeutics, Abiogen Pharma, ABIVAX, ABL Bio, Ablynx, ABX, Acacia Pharma, ACADIA Pharmaceuticals, Acasti Pharma, Acceliant, Accenture, Accord Healthcare, Accurexa, Acell, Acerta Pharma, Acer Therapeutics, Acerus, Aceto Corporation, Acetylon Pharmaceuticals, Achieve Life Science, Achillion Pharmaceuticals, AC Immune, Aclaris Therapeutics, Acrotech Biopharma, ACT Biotech, Actelion, Actigraph, Actinium Pharmaceuticals, ACT Onocology, Acturum Life, Acuity Pharmaceuticals, Acura Pharmaceuticals, Adamas Pharmaceuticals, Adaptimmune, Adaptive Biotechnologies, ADC Therapeutics, Addex Therapeutics, Adlai Nortye, Adocia, Adult Brain Tumor Consortium, Aduro BioTech, Advanced Accelerator Applications, Advanced Biological Laboratories, Advanced BioScience Laboratories, Advaxis, Aeglea BioTherapeutics, Aelix Therapeutics, Aerial 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Genomics Institute (BGI), Beijing SL Pharma, Beike Biotech, Beleave, Bellicum Pharmaceuticals, Bellus Health, Bendalis, Bened Biomedical, BenevolentAI, Benitec Biopharma, Berg, BerGenBio, Berlin Chemie, Besins Healthcare, Be The Match BioTherapies, Betta Pharmaceuticals, Bhang, BHV Pharmaceuticals, Bial, Bicycle Therapeutics, Bill and Melinda Gates Foundation, Bio-Path, Bio-Thera Solutions, BioAlliance Pharma, BioAxone Therapeutic, BioBlast Pharma, BioCardia, BioCryst Pharmaceuticals, bioCSL, BioDelivery Sciences, Biodesix, Bioeq IP, Bio Farma, Biogen, BioGenetics, Biohaven Pharmaceutical Holding, BioInvent, Biokin Pharmaceutical, BiolineRX, BioMarin Pharmaceutical, Biomedical Advanced Research and Development Authority, Biomedical Catalyst Fund (UK), Biomerica, Bioncotech Therapeutics, BiondVax, Bioniz Therapeutics, Biooutsource, Biophore Pharmaceuticals, Bioprojet, BioSense Global, BioSun Pharmed, Biothera, BioTie Therapies, BioVectra, Bioventus, BioXcel, Biscayne Neurotherapeutics, 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Addario Lung Cancer Foundation, Boryung Pharmaceutical, Boston Pharmaceuticals, Boston Strategics, Boston Therapeutics, Botanisol, Bpifrance, BrainScope, BrainStorm Cell Therapeutics, Brammer Bio, BravoVax, Breath Therapeutics, Breckenbridge Pharmaceutical, Breckenridge Pharmaceuticals, BriaCell Therapeutics, Brickell Biotech, BridgeBio Pharma, Bridge Biotherapeutics, Brigham and Women's Hospital, Brill Pharma, Bristol-Myers Squibb, Broad Institute, BTG, Burning Rock, Butantan Institute, C3i, Cachet Pharma, Cadila Pharmaceuticals, Caelum Biosciences, Caladrius Biosciences, California Institute for Regenerative Medicine, California Institute of Technology, Calithera Biosciences, Calliditas Therapeutics, Calox de Costa Rica, Camargo Pharmaceutical Services, Camurus, Can-Fite BioPharma, Canadian Brain Tumour Consortium, Canadian Cancer Trials Group, Canagen Pharmaceuticals, Canbex Therapeutics, CANbridge Life Sciences, Cancer Genetics, Cancer Prevention and Research Institute of Texas, 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Censa Pharmaceuticals, Center for Cancer Research, Center for Connected Health, Centers for Disease Control and Prevention, Centogene, Centre for Probe Development and Commercialization, Centre International de Developpment Pharmaceutique, Centre Leon Berard, Centrexion, Centurion, Cerecor, Certara, Cerulean Pharma, Cerus, Cevec Pharmaceuticals, Charite-Universitatsmedizin, Charleston Laboratories, Checkmate Pharmaceuticals, Checkpoint Therapeutics, ChemoCentryx, Chi-Med, Chiesi Farmaceutici, Children's Hospital of Philadelphia, Chimerix, China Medical System, China State Institute of Pharmaceutical Industry (CIPI), Chinese University of Hong Kong, Chong Kun Dang, Chongqing Jingdong Pharmaceutical, ChromaDex, Chugai Pharmaceutical, Chugai Pharma Marketing, Ciclofilin Pharmaceuticals, Cidara Therapeutics, Cilag AG, CiMaas, CIMAB SA, Cincinnati Children’s Hospital Medical Center, CinCor Pharma, Cingulate Therapeutics (CTx), Cipher Pharmaceuticals, Cipla, Citron Pharma, City of Hope, City of Hope Comprehensive Cancer Center, Civica Rx, CJ Corp, Clarus Therapeutics, Clearside Biomedical, Clementia Pharmaceuticals, Clene Nanomedicine, Cleveland BioLabs, Cleveland Clinic, Cleveland Diabetes Care, Clinical Genomics, Clinical Network Services, Clinigen, Clinipace Worldwide, Clovis Oncology, CMAB Biopharma, CMC Biologics, CMS Medical, CNS Pharmaceuticals, Coalition for Epidemic Preparedness Innovations, Codexis, Cofactor Genomics, Cognition Therapeutics, Coherus Biosciences, Cold Genesys, Coldstream Laboratories, Collaborative Study Group, Collegium Pharmaceuticals, Color Genomics, Columbia Care, Columbia University, Complement Pharma, Compugen, Conatus Pharmaceuticals, Concert Pharmaceuticals, Confluence Pharmaceuticals, Connecticut Innovations, Constance Therapeutics, Context Therapeutics, ContraVir Pharmaceuticals, ConverGene, Cook Biotech, Cook Medical, Corbus Pharmaceuticals, Corcept Therapeutics, CORD:USE, CoreRx Pharma, Corino Therapeutics, Cornell University, 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Cyxone, Daewoong Pharmaceutical, Daiichi Sankyo, Dainippon Sumitomo Pharma, Dako, DalCor Pharmaceuticals, Dalhousie University, Dalton Pharma Services, Dana-Farber Cancer Institute, Dance Biopharm, DanDrit Biotech, DARA BioSciences, Dare Bioscience, Dassault Systems, DAS Therapeutics, Davospharma, DBV Technologies, DCPrime, Debiopharm, DecImmune Therapeutics, Deciphera Pharmaceuticals, Defense Advanced Research Projects Agency, Defense Threat Reduction Agency, Delcath Systems, DelMar Pharmaceuticals, Deltamune, Denali Therapeutics, Denovo Biopharma, Department of Defense, Department of Health and Human Services, Department of Veterans Affairs, Dermavant Sciences, Dermin, Dermira, Destiny Pharma, DeuteRx, Dexcel Pharma, DiaMedica, Dilafor, Dilaforette, Dipexium Pharmaceuticals, Discovery Laboratories, Diurnal, DNAtrix, Domainex, Dong-A Pharmaceutical, Dongbao, Dr. Falk Pharma, Dr. Reddy's Laboratories, Dragonfly Therapeutics, DreaMed Diabetes, Drugs for Neglected Diseases Initiative, DSG, DuChemBio, Duchenne UK, Duchesnay, Duke-NUS Graduate Medical School Singapore, Duke Cancer Institute, Duke University, Durata Therapeutics, Durect, Dutch-Belgian Cooperative Trial Group for Hematology Oncology (HOVON), Dynasil, Dynavax Technologies, Dyne Therapeutics, DynPort Vaccine Company, DySIS Medical, Dystonia Medical Research Foundation, Eagle Pharmaceuticals, Eastar Industries, Eastern Cooperative Oncology Group, EB Pharma, EDAP TMS, Eddingpharm, Edge Medical, Edison Pharmaceuticals, Educational and Scientific, eFFECTOR Therapeutics, EffRx, EGeen, EicOsis, Eiger BioPharmaceuticals, EirGenix, EirGen Pharma, Eisai, Eisai Inc, Elanco, Eleven Biotherapeutics, Elicio Therapeutics, Eli Lilly, Elite Pharmaceuticals, Ellipses Pharma, Emerald Logic, Emerge Health, Emergent BioSolutions, Emmaus Life Sciences, Emmes, Emory University, EMS, Emtora Biosciences, EndoCeutics, Endocyte, Endo International, EndoLogic, Endo Pharmaceuticals, Endospan, Enlivex, Entasis Therapeutics, Enteris 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