Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020

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The Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report provides comprehensive understanding and unprecedented access to the discovery stage partnering agreements entered into by the worlds leading biopharma companies.

Publication date
March 2020
Number of pages
1,500+
Product type
Research report
Available formats
PDF document
Report edition
4
SKU
CP2056

The Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report.

 

The report provides a detailed understanding and analysis of how, why and on what terms companies enter discovery stage partnering deals. These deals are discovery stage whereby the licensee obtains a right or an option right to license the licensors product or technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes.

 

This report provides details of the latest discovery agreements announced in the healthcare sector.

 

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases and databases do not.

 

This report contains a comprehensive listing of all discovery stage partnering deals announced since 2014 including financial terms where available including over 2,500 links to online deal records of actual discovery partnering deals as disclosed by the deal parties. In addition, where available, records include contract documents as submitted to the Securities Exchange Commission by companies and their partners.

 

Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.

 

The initial chapters of this report provide an orientation of discovery stage deal making and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an overview of why companies partner discovery stage compounds/products.

 

Chapter 3 provides an overview of discovery stage deals strategy and deal structure including numerous case studies. Chapter 4 provides an overview of the various payment strategies used in discovery stage deals.

 

Chapter 5 provides a review of discovery stage deal making since 2014. Deals activity is reviewed by year, therapeutic area, technology type, as well as most active dealmakers.

 

Chapter 6 provides a detailed analysis of discovery stage payment terms including headline, upfront, milestone and royalty rates.

 

Chapter 7 provides a review of the leading discovery stage deal by headline value. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand. 

 

Chapter 8 provides a comprehensive listing of the top 25 most active discovery stage dealmaker companies. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand. 

 

Chapter 9 provides a comprehensive and detailed review of discovery stage partnering deals signed and announced since 2014, where a contract document is available in the public domain.

 

Chapter 10 provides a comprehensive directory of discovery stage partnering deals since 2014.

 

The report includes deals announced by hundreds of life science companies including big pharma such as Abbott, Abbvie, Actavis, Amgen, Astellas, AstraZeneca, Baxter, Bayer, Biogen Idec, BMS, Celgene, Eisai, Eli Lilly, Gilead, GSK, J&J, Kyowa Hakko, Merck, Mitsubishi, Mylan, Novartis, Pfizer, Roche, Sanofi, Shire, Takeda, Teva, and Valeant, amongst many others.

 

The report also includes numerous tables and figures that illustrate the trends and activities in discovery stage partnering and deal making since 2014.

 

In addition, a comprehensive appendix of all discovery deals since 2014 is provided organized by partnering company A-Z, deal type, therapy focus and technology type. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

 

In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of discovery stage products and compounds.

 

Key benefits

 

Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 provide the reader with the following key benefits:

 

  • In-depth understanding of discovery stage deal trends since 2014
  • Access to headline, upfront, milestone and royalty data
  • Analysis of the structure of discovery stage agreements with numerous real life case studies
  • Insight into the terms included in a discovery stage agreement, together with real world clause examples
  • Understand the key deal terms companies have agreed in previous deals           
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies

 

Report scope

 

Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 is intended to provide the reader with an in-depth understanding and access to discovery stage deal trends and structure of deals entered into by leading companies worldwide.

 

Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 include:

 

  • Trends in discovery stage dealmaking in the biopharma industry since 2014
  • Analysis of discovery stage deal structure
  • Access to headline, upfront, milestone and royalty data
  • Case studies of real-life discovery stage deals
  • Access to over 2,500 discovery stage deals
  • The leading discovery stage deals by value since 2014
  • Most active discovery stage dealmakers since 2014
  • The leading discovery stage partnering 2014

 

In Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020, the available contracts are listed by:

 

  • Company A-Z
  • Headline value
  • Stage of development at signing
  • Deal type
  • Specific therapy target

 

Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

 

The Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report provides comprehensive access to available deals and contract documents for over 2,500 discovery stage deals. Analyzing actual contract agreements allows assessment of the following:

 

  • What are the precise rights granted or optioned?
  • What is actually granted by the agreement to the partner company?
  • What exclusivity is granted?
  • What is the payment structure for the deal?
  • How aresalesand payments audited?
  • What is the deal term?
  • How are the key terms of the agreement defined?
  • How are IPRs handled and owned?
  • Who is responsible for commercialization?
  • Who is responsible for development, supply, and manufacture?
  • How is confidentiality and publication managed?
  • How are disputes to be resolved?
  • Under what conditions can the deal be terminated?
  • What happens when there is a change of ownership?
  • What sublicensing and subcontracting provisions have been agreed?
  • Which boilerplate clauses does the company insist upon?
  • Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
  • Which jurisdiction does the company insist upon for agreement law?

Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2014-2020 report provides the reader with the following key benefits:

 

  •  In-depth understanding of discovery stage deal trends since 2014
  • Access to headline, upfront, milestone and royalty data
  • Comprehensive access to over 2,500 discovery stage deals together with contract documents if available
  • Detailed access to actual discovery stage deals entered into by the leading fifty big pharma and big biotech companies along with other biopharma companies
  • Analysis of the structure of discovery stage agreements with numerous real life case studies
  • Identify leading discovery stage deals by value since 2014
  • Identify the most active discovery stage dealmakers since 2014
  • Full listing of discovery stage deals by company A-Z, phase of development, deal type, therapy and technology focus
  • Understand the key deal terms companies have agreed in previous deals          
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies

Executive Summary

 

Chapter 1 – Introduction

 

Chapter 2 – Why do companies partner at discovery stage?

 

2.1. Introduction

2.2. The role of discovery stage partnering

2.2.1. In-licensing at discovery stage

2.2.2. Out-licensing at discovery stage

2.3. Difference between discovery, preclinical and clinical stage deals

2.4. Reasons for entering into discovery stage partnering deals

2.4.1. Licensors reasons for entering discovery stage deals

2.4.2. Licensees reasons for entering discovery stage deals

2.5. The future of discovery stage partnering deals

 

Chapter 3 – Discovery stage deal strategies and structure

 

3.1. Introduction

3.2. At what stage do companies partner?

3.2.1. Partnering early in pharmaceutical/biotech

3.2.1.1. Discovery and preclinical stage partnering case studies

3.2.1.1.a. Case study: LEO Pharma - 4SC

3.2.1.1.b. Case study: Heptares Therapeutics - Cubist

3.2.1.1.c. Case study: Incyte – Agenus Bio

3.2.1.1.d. Case study: Janssen Pharmaceutical - Evotec

3.2.2. Partnering later in pharmaceutical/biotech

3.2.2.1. Clinical stage partnering case studies

3.2.2.1.a. Case study: Servier – GeNeuro

3.2.2.1.b. Case study: Teva – Xenon Pharmaceuticals

3.2.2.1.c. Case study: AstraZeneca - Ardelyx

3.2.2.1.d. Case study: Baxter – Onconova Therapeutics

3.3. Early and later stage partnering – a risk/cost comparison

3.4. What do companies spend on discovery, preclinical and clinical stage partnering?

3.5. Pure versus multi-component partnering deals

3.6. Pure licensing agreement structure

3.6.1. Example pure licensing agreements

3.6.1.a. Case study : Pfizer – Spark Therapeutics

3.6.1.b. Case study : Contrafect – Trellis Bioscience

3.7. Multicomponent discovery stage partnering agreements

3.7.1.a. Example multicomponent early stage clauses

3.7.1.a. Case study: Tracon – Boehringer Ingelheim – Macrogenics

3.7.1.b. Case study: Fibrocell Science – Intrexon

 

Chapter 4 – Discovery stage partnering payment strategies

 

4.1. Introduction

4.2. Discovery stage payment strategies

4.3. Payment options

4.3.1. Headline values

4.3.2. Upfront payments

4.3.2.1. Conditionality of upfront payments

4.3.3. Loans

4.3.4. Convertible loans

4.3.5. Equity

4.3.6. R&D funding

4.3.7. Licensing fees

4.3.8. Milestone payments

4.3.9. Royalty payments

4.3.9.1. Issues affecting royalty rates

4.3.9.2. Royalties on combination products

4.3.9.2.a. Case study: Scripps Research Institute-Cyanotech

4.3.9.3. Guaranteed minimum/maximum annual payments

4.3.9.4. Royalty stacking

4.3.9.5. Royalties and supply/purchase contracts

4.3.10. Quids

4.3.11. Option payments

 

Chapter 5 – Trends in discovery stage deal making

 

5.1. Introduction

5.2. Discovery stage partnering over the years

5.2.1. Attributes of discovery deals

5.3. Discovery stage partnering by deal type

5.4. Discovery stage partnering by disease type

5.5. Partnering by discovery stage technology type

5.6. Discovery stage partnering by most active company since 2014

 

Chapter 6 – Payment terms for discovery stage partnering

 

6.1. Introduction

6.2. Guidelines for discovery stage payment terms

6.2.1. Upfront payments

6.2.2. Milestone payments

6.2.3. Royalty payments

6.3. Discovery stage payment terms – deal data analysis

6.3.1. Public data

6.3.2. Survey data

6.4. Payment terms analysis

6.4.1. Discovery stage headline values

6.4.2. Discovery stage deal upfront payments

6.4.3. Discovery stage deal milestone payments

6.4.4. Discovery stage royalty rates

 

Chapter 7 – Leading discovery stage deals

 

7.1. Introduction

7.2. Top discovery stage deals by value

 

Chapter 8 – Top 25 most active discovery stage dealmakers

 

8.1. Introduction

8.2. Top 25 most active discovery stage dealmakers

 

Chapter 9 – Discovery stage partnering contracts directory

 

9.1. Introduction

9.2. Discovery stage deals with contracts 2014 to 2020

 

Chapter 10 – Discovery stage deal making by development stage

 

10.1. Introduction

10.2. Deals by discovery stage

 

Appendices

 

Appendix 1 – Discovery stage dealmaking by companies A-Z

Appendix 2 – Discovery stage dealmaking by industry sector

Appendix 3 – Discovery stage dealmaking by stage of development

Appendix 4 – Discovery stage dealmaking by therapy area

Appendix 5 – Discovery stage dealmaking by technology type

 

About Wildwood Ventures

 

Current Partnering

Current Agreements

Recent report titles from CurrentPartnering

 

Table of figures

 

Figure 1: Definition of discovery, preclinical and clinical phases in dealmaking
Figure 2: Components of the pure licensing deal structure
Figure 3: Payment options for discovery stage partnering deals
Figure 4: Issues affecting royalty rates
Figure 5: Discovery stage partnering frequency 2014- 2020
Figure 6: Discovery stage partnering by deal type since 2014
Figure 7: Discovery stage partnering by disease type since 2014
Figure 8: Discovery stage partnering by technology type since 2014
Figure 9: Top 25 most active discovery stage dealmakers, 2014 to 2020
Figure 10: Review of median upfront payments for discovery stage deals
Figure 11: Review of median milestone payments for discovery stage deals
Figure 12: Review of median royalty payments for discovery stage deals
Figure 13: Discovery stage deals with a headline value
Figure 14: Discovery stage deals with an upfront value
Figure 15: Discovery stage deals with a milestone value
Figure 16: Discovery stage deals with a royalty rate value
Figure 17: Top discovery stage deals that exceeds $1 billion in deal value since 2014
Figure 18: Most active discovery stage dealmakers 2014 to 2020

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1CellBiO, 1ST Biotherapeutics, 2A, 3B Pharmaceuticals, 3SBio, 4D Molecular Therapeutics, 4D Pharma, 10X Genomics, 14M Genomics, 22nd Century, 23andMe, 48Hour Discovery, A*STAR Agency for Science, Technology and Research, A*STAR Genome Institute of Singapore, A*STAR’ Institute of Molecular and Cell Biology, A-Alpha Bio, A.I. Squared, A1M Pharma, A2A Pharmaceuticals, Abbvie, Abby Grace Foundation, Abcam, AbCellera, AbCheck, Abcuro, Abeona Therapeutics, Abide Therapeutics, Abilita Bio, Ab Initio, ABL Bio, Ablexis, Ablynx, AbMed, Abpro, Abramson Cancer Center, Abveris, Abzena, Academic Drug Discovery Consortium, Acceleron Pharma, Accelovance, Accenture, ACEA Biosciences, Acerta Pharma, Acetylon Pharmaceuticals, AC Immune, Actavis (name changed to Allergan), Actelion, Actinium Pharmaceuticals, ActoGeniX, AcuraStem, Adagene, AdAlta, Adapsyn Bioscience, Adaptate Biotherapeutics, Adaptimmune, Adaptive Biotechnologies, Adaptive Phage Therapeutics, ADC Therapeutics, Adimab, AdoRx Therapeutics, ADT Pharmaceuticals, Aduro BioTech, Advaita, Advaite, Advanced Biological Laboratories, Advanced Proteome Therapeutics, Advaxis, Adverum Biotechnologies, Adynxx, Aelan Cell Technologies, Aeras, AEterna Zentaris, Aetion, Aevi Genomic Medicine, Aevitas Therapeutics, Affibody, Affimed Therapeutics, Affinivax, AFFiRiS, Affymetrix, AffyXell Therapeutics, Afraxis, AgBiome, Age Labs, Agendia, Agensys, Agenus Bio, AgeX Therapeutics, Agilent Technologies, Agilis Biotherapeutics, AgomAb Therapeutics, AgonOx, AGTC, AiCuris, AiVita Biomedical, AKESOgen, Akili Interactive Labs, Akouos, Akoya Biosciences, Akrevia Therapeutics, Akriveia Therapeutics, Albert Einstein College of Medicine, Albumedix, Alderley Analytical, Aldevron, Aldeyra Therapeutics, Alector, Alexion Pharmaceuticals, Algenex, AliHealth, AlivaMab Discovery Services, Alize Pharma, ALK-Abello, Alkahest, Alkermes, Allakos, Allele Biotechnology and Pharmaceuticals, Allen Institute for Brain Science, Allergan, Allied-Bristol Life Sciences, Alligator Bioscience, Allogene Therapeutics, Almac Discovery, Almac Group, Almirall, Alnylam Pharmaceuticals, Alpine Immune Sciences, ALS Association, ALS Biopharma, Altasciences, Alteogen, Alytas Therapeutics, Alzheimer's Association, Alzheimer's Drug Discovery Foundation, Alzheimer's Foundation of America, Alzheimer's Research UK, Alzheimer Society Research, Alzheimers Research UK, Amarantus BioSciences, Amarna Therapeutics, Amazon Web Services, Ambrx, Ambys Medicines, American Academy of Ophthalmology, American Association for Cancer Research, American BriVision, American Cancer Society, American Diabetes Association, American Lung Association, American National Multiple Sclerosis Society, American Skin Association, American Society of Clinical Oncology (ASCO), American Society of Hematology, Amfora, Amgen, Amicus Therapeutics, AmorChem, AmpliPhi Biosciences, AMR, AMRA, Amunix, Amyris, AnaBios, Anaeropharma, Analysis Group, Analytical Biological Services, Analytics Engines, AnaMar, ANANDA Scientific, Anandia Laboratories, Anchiano Therapeutics, AnGes MG, Angle, Anika Therapeutics, Anima Biotech, Anji Pharma, Annette Funicello Research Fund for Neurological Diseases (AFRFND), Annoroad, ANP Technologies, Antengene, Anterios, Anthem, Antibody Solutions, Antikor Biopharma, Antitope, Apeiron Biologics, Aphios, Applied BioMath, APRINOIA Therapeutics, Aptahem, Aptamer Therapeutics, Aptose Biosciences, Aptuit, Aqilion, Aquinnah Pharmaceuticals, Arbele, Arbor Biotechnologies, Arbutus, Arcadia Biosciences, Arcturus Therapeutics, Ardelyx, Ardent Mills, Arena Pharmaceuticals, Ares Genetics, Ares Life Sciences, arGEN-X, argenx, Argos Therapeutics, Ariad Pharmaceuticals, Ariana Pharma, Aridis Pharmaceuticals, Arisaph Pharmaceuticals, Arix Bioscience, Ark Biosciences, ARMO Biosciences, Aro Biotherapeutics, Arpeggio Biosciences, Arrakis Therapeutics, Array Biopharma, Arrevus, Arrow Pharmaceuticals, Artelo Biosciences, Artes Biotechnology, Artialis, Artios Pharma, Artizan Biosciences, Arvinas, Arzeda, Asahi Kasei, Asana Biosciences, Asceneuron, Ascenion, ASKA Pharmaceuticals, Asklepios Biopharmaceutical, Aspira Scientific, Aspyrian Therapeutics, Astellas Pharma, Astex Pharmaceuticals, Asthma UK, AstraZeneca, Atara Biotherapeutics, Ataxion, aTen Therapeutics, Athenex, Atomwise, Atossa Genetics, Atrapos Therapeutics, Atreca, Atropos Therapeutics, ATUM, Atvio Biotech, aTyr Pharma, Auburn University, Audentes Therapeutics, Audion Therapeutics, AUM Biotech, Aural Analytics, Aurigene Discovery Technologies, Auris Medical, Auron Therapeutics, Australian Department of Health and Ageing, Australian Foundation for Diabetes Research, Australian Research Council, Autifony Therapeutics, Autodesk, Autolus, Avacta, Avactis Biosciences, Avalon GloboCare, AvantGen, Avidity Biosciences, Avidity NanoMedicines, Avita Medical, Axcelead Drug Discovery Partners, Axcella, Axiogenesis, AxioMx, Axis Therapeutics, Axovant Sciences, Axxam, AyoxxA Biosystems, AzurRx BioPharma, B-MoGen Biotechnologies, Babraham Institute, Bacit, Bactevo, Barbara Ann Karmanos Cancer Institute, Baruch S Blumberg Institute, BASF, Basilea Pharmaceutica, Batavia Biosciences, Battelle, Baudry Laboratory, Bavarian Nordic, Baxalta, Baxter International, Bayer, Bayer Healthcare, Baylor College, Baylor College of Medicine, Baylor Institute for Immunology Research, Baylor Miraca Genetics Laboratories, BCD Bioscience, BD Biosciences, Beacon Discovery, Beactica, Beam Therapeutics, BeiGene, Bellerophon Therapeutics, Bellicum Pharmaceuticals, Ben-Gurion University, Benchwise, BenevolentAI, Benitec Biopharma, Berg, Berkeley Lights, Beroni Group, Bertin Pharma, Beta Therapeutics, Be The Match BioTherapies, Beth Israel Deaconess Medical Center, Beyond Batten Disease Foundation, BGN Technologies, Biametrics, Bicycle Therapeutics, Bill and Melinda Gates Foundation, BIND Therapeutics, Bio-Cancer Treatment International, Bio-Rad Laboratories, Bio-Techne, BioArctic Neuroscience, biOasis Technologies, BIOASTER, BioAtla, BioBlast Pharma, Bioblock, BioBright, Biocept, BioCision, Biocodex Microbiota Foundation, BioCurate, Biodextris, BioFluidica, Biofourmis, Biogen, Biognosys, Biohaven Pharmaceutical Holding, BioInvent, BioIVT, BioLegend, BiolineRX, Biolin Scientific, BioLite Japan, Biomed Elements, Biomedical Advanced Research and Development Authority, Biomedical Catalyst Fund (UK), BioMed Realty Trust, BioMed X Innovation Center, bioMerieux, Biomica, Biomillenia, BioMotiv, Biomunex Pharmaceuticals, BiomX, BioNano Genomics, Bioneer, Bionetix, Bioniz Therapeutics, BioNovion, BioNTech, BionX Medical Technologies, Bioo Scientific, Bio Palette, BioPontis Alliance, BioReference Laboratories, Biorelate, BioReliance, BioRestorative Therapies, Biosceptre International, Biosearch Technologies, BioSolveIT, Biostar Pharmaceuticals, Biotechnology and Biological Sciences Research Council (BBSRC), Biotem, Biothera, Biotheus, BioVaxys, Bioverativ, BioVersys, BioXcel, Bioz, BirchBioMed, Bird Foundation, Bit Bio, Blackfynn, BlackThorn Therapeutics, BlinkBio, BliNK Biomedical, Bliss Biopharmaceutical, Blockchain Global, Bloom Burton, Bloom Science, Bluebird Bio, Blue Buffalo Company, Blue Cross Blue Shield Association, Bluefield Innovations, Blueprint Medicines, BlueRock Therapeutics, Blue Water Vaccines, Boehringer Ingelheim, Boehringer Ingelheim Vetmedica, Bonbouton, Bone Therapeutics, Bonnie J. Addario Lung Cancer Foundation, Boragen, Boston Biomedical, BostonGene, Boston University, Boston University School of Medicine, Botanisol, Boulos and Cooper Pharmaceuticals, Bpifrance, Brain & Behavior Research Foundation, Brain Biomarker Solutions in Gothenburg, Brain Science Foundation, BravoVax, BRCA Foundation, Breath Diagnostics, BrickBio, Brickell Biotech, BridgeBio Pharma, Brigham and Women's Hospital, BrightFocus Foundation, Brighton Biotech, Brii Biosciences, BRIM Biotechnology, Bristol-Myers Squibb, British Pharmacological Society, Broad Institute, Brown University, Buck Institute for Age Research, BullFrog AI, Burnet Institute, C2N Diagnostics, C4 Therapeutics, C4X Discovery, Caerus Discovery, Caladrius Biosciences, Calico, California Institute for Biomedical Research, California Institute for Quantitative Biosciences (QB3), California Institute for Regenerative Medicine, California Institute of Technology, Calimmune, Calithera Biosciences, Calixar, Calyxt, Cambridge Enterprise, Camino Pharma, CAMP4 Therapeutics, CANbridge Life Sciences, Cancer Australia, Cancer Immunotherapy Trials Network, Cancer Prevention and Research Institute of Texas, Cancer Research Institute, Cancer Research Technology, Cancer Research UK, Cantab Anti-infectives, Capnia, Capricor Therapeutics, CARB-X, Carbiotix, Cardiff University, Cardinal Partners, Cardurion Pharmaceuticals, Caribou Biosciences, Caris Life Sciences, Carmentix, Carmot Therapeutics, Carna BioSciences, Carnot BioSciences, Carolina BioOncology Institute, CARsgen, Cartana, Cartherics, Casebia Therapeutics, Case Western Reserve University, Casma Therapeutics, CasZyme, Catalan Institute of Nanotechnology (ICN), Catalent, Catholic University Leuven, CavoGene LifeSciences, CBT Pharmaceuticals, Cedars-Sinai Medical Center, CEITEC, Celgene, Cell2in, Celladon, Cellaria Biosciences, Cellecta, Cellectar Biosciences, Cellect Biotechnology, Cellectis, Cellesce, CELLINK, Cell Medica, Cell Mogrify, Cellthera Pharma, Cell Therapy Catapult, Celltrion, Cellular Biomedicine, Cellular Dynamics International, Cellular Research, Celmatix, Celonic, Celsius Therapeutics, Cenix BioScience, Centene, Center for Biomarker Research in Medicine, Center for Human Genetics and Laboratory Medicine, Center for Human Immunology, Autoimmunity and Inflammation, Center for Infectious Disease Research, Center for iPS Cells Research and Application, Centogene, Centre for Commercialization of Regenerative Medicine (CCRM), Centre for Drug Research and Development (CDRD), Centre For Proteomic & Genomic Research, Centre Hospitalier Régional Universitaire (CHRU) de Lille, Centre Hospital University - Bordeaux, Centre Leon Berard, Centre National de Biologie Expérimentale, Centre National de la Recherche Scientifique, Century Therapeutics, Cepheid, Cerevance, Certara, Cerveau Technologies, Ceva Sante Animale, Cevec Pharmaceuticals, Chan Zuckerberg Initiative, Chaperone Technologies, Charles River Laboratories, CHDI Foundation, Checkpoint Therapeutics, ChemDiv, ChemRar High-Tech Center, Chiesi Farmaceutici, Children's Heart Foundation, Children's Hospital Boston, Children's Hospital Los Angeles, Children's Hospital of Philadelphia, Children's Hospital Of Wisconsin, Children's Medical Research Institute, Children's National Health System, China-Singapore Guangzhou Knowledge City, China National Biotech Group (CNBG), China Southeast University, Chinese Academy of Agricultural Science, Chinese Academy of Sciences, Chiome Bioscience, Chiromics, Chongqing Lummy Pharma, Christian Doppler Research Association, Chronos Therapeutics, Chugai Pharmaceutical, Cidara Therapeutics, Cincinnati Children’s Hospital Medical Center, Cinda Bio-Pharmaceutical, Circuit Clinical, Circuit Therapeutics, Cisen Pharma, City of Hope, Civetta Therapeutics, Clalit Health Services, Clarity Pharmaceuticals, Cleara Biotech, Clearbridge Biomedics, ClearLight Diagnostics, ClearPath, Clene Nanomedicine, Cleveland Clinic, Cleveland HeartLab, Cleveland University Hospitals, Clevexel Pharma, Cloud Pharmaceuticals, Clover Therapeutics, Clovis Oncology, CNA Development, Co-Diagnostics, Coalition for Epidemic Preparedness Innovations, Cobra Biologics, Cocrystal Pharma, Codexis, Codiak BioSciences, COFCO Group, Cognition Therapeutics, Cohen Veterans Bioscience, Cold Spring Harbor, Collaborative Trajectory Analysis Project, Columbia University, Columbia University Medical Center, Complix, Compugen, Concept Life Sciences, Concerto HealthAI, Confo Therapeutics, Congenica, Conkwest, Connecticut Children’s Medical Center, ConsortiaTX, Consortium AI, Context Therapeutics, Contextual Genomics, ContraFect, ContraVir Pharmaceuticals, Convelo Therapeutics, Cooperative Research Centre for Cell Therapy Manufacturing, Cord Blood Registry, CoreBiome, Corestem, Cornell University, Coronado Biosciences, Corporation for Biological Research, Corteva Agriscience, Cortexyme, Corvidia Therapeutics, COTA, COUR Pharmaceutical, Courtagen Life Sciences, Covalab, Covalent Data, Covaris, Create Vaccine Company, Creative Destruction Lab, Creative Medical Technologies, Crescendo Biologics, Cresset, Crestone Pharma, CRISPR Therapeutics, Cristal Therapeutics, Crohn's and Colitis Foundation of America, Crossbeta Biosciences, Crown Bioscience, Crystal Bioscience, CSL Behring, CTI BioPharma, Cue Biopharma, Cullinan Oncology, Cumberland Emerging Technologies, Cumberland Pharmaceuticals, Curable, Curadev Pharma, CureCell, Cure Duchenne, Cure Sanfilippo Foundation, Cure SMA, Cures Within Reach, Curetis, CureVac, Curie-Cancer, Curiox Biosystems, Curis, Cyclenium Pharma, Cyclica, Cyclotek, Cynata Therapeutics, Cypher Genomics, Cyrus Biotechnology, Cystic Fibrosis Foundation, Cystic Fibrosis Foundation Therapeutics, Cystinosis Research Foundation, CytoLumina Technologies, CytomX Therapeutics, Cytoo, CytoReason, CytoSen Therapeutics, Cytovant Sciences, CYTOVIA Therapeutics, Cytox, Daewoong Pharmaceutical, Daiichi Sankyo, Dainippon Sumitomo Pharma, Dalhousie University, Dana-Farber Cancer Institute, DarwinHealth, Datavant, David H. Koch Institute for Integrative Cancer Research, Da Volterra, DayTwo, Debiopharm, Decibel Therapeutics, deCODE Genetics, Deerfield Management, Defense Advanced Research Projects Agency, Defense Threat Reduction Agency, DefiniGEN, DeGregorio Family Foundation, Deinove, Dementia Consortium, Dementia Discovery Fund, Denali Therapeutics, Dendreon, DendroCyte, Department of Defense, Department of Economic development of Montgomery County, Department of Health and Human Services, Department of Veterans Affairs, DePuy, Dermala, Dermelix Biotherapeutics, Desktop Genetics, DestiNA Genomics, Devonian Health Group, Dewpoint Therapeutics, DiamiR, Diamond Light Source, Diatheva, DiCE Molecules, Dicerna Pharmaceuticals, Dimension Therapeutics, DiNAQOR, Disc Medicine, Distributed Bio, DNAnexus, DNA Script, DNAtrix, Dolomite Bio, Domainex, Domain Therapeutics, Dorian Therapeutics, Dow AgroSciences, Dr. Susan Love Research Foundation, Dragonfly Therapeutics, Dresner Foundation, Drugs for Neglected Diseases Initiative, Drukier Institute for Children's Health, Dualogics, Duke Clinical Research Institute (DCRI), Duke University, Dyadic International, DyNAbind, Dynamic Combinatorial Chemistry, DZNE German Center for Neurodegenerative Diseases, E-Scape Bio, E-Therapeutics, E.T. Horn, E3x Bio, Eagledream Health, Eagle Genomics, ECM Therapeutics, Ecole Polytechnique Federale de Lausanne, Edge Therapeutics, Edico Genome, EdiGene, Edison Nation Medical, Edison Pharmaceuticals, Editas Medicine, eFFECTOR Therapeutics, Eirion Therapeutics, Eisai, Eisai Inc, Elanco, Elasmogen, Elevian, Eli Lilly, Elixirgen, Ellison Medical Foundation, Elpis Biomed, Elpiscience, Elsevier, Elucidata, Embark Biotech, EMD Serono, Emendo Biotherapeutics, Emergence Therapeutics, Emergent BioSolutions, Emergex Vaccines, Emory University, Empirico, Enamine, EnBiotix, Encycle Therpaeutics, Endo Pharmaceuticals, Energesis Pharmaceuticals, enGene, Engineered Medical Solutions, Engitix, Enigma Biomedical, Enleofen Bio, Enlibrium, Enterome Bioscience, Enthera, Enumeral Biomedical, ENYO Pharma, EpiBiome, Epic Sciences, Epilepsy Society, Epivax, Epizyme, Erasmus University Medical Center, ERS Genomics, Ervaxx, ES Cell International, Escient Pharmaceuticals, Esophageal Cancer Awareness Association, 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Komen for the Cure, Sutro Biopharma, Suzhou NeuPharma, SV Life Science, Sway Medical, Swedish Orphan Biovitrum, Syapse, Sygnature Discovery, Symphogen, Synaffix, Synbiotic Health, Syncona Partners, Syndesi Therapeutics, Synergy Partners R&D Solutions, Syngenta, Syngulon, Synlogic, Synpromics, Synthego, Synthetic Biologics, Synthetic Genomics, Syros Pharmaceuticals, Systimmune, Taconic Biosciences, Taiho, TaiRx, Taisho Pharmaceutical, Takeda America Holdings, Takeda Pharmaceutical, Takeda Ventures, Takis, Talem Therapeutics, TamRx, Tanabe Research Laboratories, Tango Therapeutics, TAP Biosystems, TARA Biosystems, Targacept, Targazyme, Target ALS Foundation, TARGET PharmaSolutions, Targovax, TARIS Biomedical, Taros Chemicals, Tau Consortium, TB Alliance, TBD Biodiscovery, TC BioPharm, Team Sanfilippo, Technical University of Denmark (DTU), Technion Research and Development Foundation, Technology Foundation STW, Technology Strategy Board (UK), Technology Transfer Accelerator, Technology University Dresden, TechnoVax, Teijin, Tel Aviv Sourasky Medical Center, Tel Aviv University, Telix Pharmaceuticals, Temple University, Tempus, Tencent Holdings, TeneoBio, Tesaro, TeselaGen, TES Pharma, Tessa Therapeutics, Tetra Discovery Partners, Tetragenetics, Teva Pharmaceutical Industries, Texas A&M University, Texas Children’s Hospital, Texas Christian University, TG Therapeutics, The American Senior Housing Association, The Global Stem Cell and Regenerative Medicine Acceleration Center (GSRAC), The Haematological Malignancy Research Network, The Human Protein Atlas, The International AIDS Vaccine Initiative, The Medicines Company, Themis Bioscience, The New York Stem Cell Foundation, The Parker Institute For Cancer Immunotherapy, Theradiag, Theravectys, The Regents of the University of California, Theresia G & Stuart F Kline Family Foundation, Thermo Fisher Scientific, The Silverstein Foundation for Parkinson's, The University of Chicago Medicine, Thiel Foundation, Thomas Jefferson University, Thought Leadership & Innovation Foundation, Thrive Bioscience, ThromboGenics, Tianjin CanSino Biotechnology, Tianjin University, Tillotts Pharma, Tissue Regeneration Systems, Titian Software, Tiziana Life Sciences, Tizona Therapeutics, T Med, Tmunity Therapeutics, TNK Therapeutics, TNO Pharma, TomegaVax, Toolgen, TopAlliance Biosciences, Torch Biosciences, Toronto Innovation Acceleration Partners, Torrey Pines Institute for Molecular Studies, Torrey Pines Investment, Tor Vergata University Hospital, Toulouse University Hospital, Tow Foundation, Toyota Motor, TPG Biotech, TRACON Pharmaceuticals, Trakcel, TransBio, TransChem, Transcriptic, Transgene, Transgenomic, Translate Bio, Translational Genomics Research Institute, Translatum Medicus, Transporin, Transposagen Biopharmaceuticals, TransTech Pharma, Trefoil Therapeutics, Trellis Bioscience, Trenzyme, Treventis, Tri-Institutional Therapeutics Discovery Institute, Trianni, Trieza Therapeutics, Triphase Accelerator, TrojanTec, Tsinghua University, Tuberous Sclerosis Alliance (TS Alliance), Tubulis, Tu Dresden, Tufts University, TuHURA Biopharma, TumorGenesis, Turku PET Center, Turnstone Biologics, Twist Bioscience, twoXAR, TxCell, Tyber Medical, Ubiquigent, UbiVac, UCB, UH Harrington Discovery Institute, UK Cystic Fibrosis Gene Therapy Consortium, UK Government, Ultragenyx Pharmaceuticals, UMN Pharma, UNeMed, UNICANCER, UniQuest, UniQure, Univeristy of Durham, Universal Cells, Universite Claude Bernard Lyon, Universite Laval, University Ann & Robert H. Lurie Children’s Hospital, University City Science Center, University College Cork, University College London, University Gottingen, University Health Network, University Hospitals Rainbow Babies & Children's Hospital, University Medical Center Groningen, University Medical Center Utrecht, University of Alabama, University of Alabama at Birmingham, University of Alberta, University of Amsterdam, University of Arizona, University of Arkansas, University of Barcelona, University of Basel, University of Bonn, University of Bristol, University of British Columbia, University of Buffalo, University of California, University of California, Davis, University of California, San Diego, University of California, San Diego (UCSD) School of Medicine, University of California Berkeley, University of California Irvine, University of California Los Angeles, University of California San Francisco, University of California Santa Cruz, University of Cambridge, University of Chicago, University of Cincinnati, University of Colorado, University of Colorado Denver, University of Connecticut, University of Debrecen, University of Dundee, University of Eastern Finland, University of Edinburgh, University of Exeter, University of Florida, University of Florida Research Foundation, University of Geneva, University of Greifswald, University of Heidelberg, University of Hong Kong, University Of Huddersfield, University of Illinois, University of Illinois Urbana-Champaign, University of Iowa, University of Jaen, University Of Jyvaskyla, University of Kansas, University of Kentucky, University of Kiel, University of Leeds, University of Leipzig, University of Manchester, University of Manitoba, University of Maryland, University of Maryland Baltimore, University of Massachusetts, University of Massachusetts Medical School, University of Melbourne, University of Miami, University of Michigan, University of Michigan Medical School, University of Minnesota, University of Montreal, University of Nagasaki, University of Nebraska, University of New Hampshire, University of New Mexico, University of New South Wales, University of North Carolina, University of Northern Colorado, University of North Texas Health Science Center, University of Notre of Dame, University of Nottingham, University of Oklahoma, University of Oslo, University of Oxford, University of Pennsylvania, University of Pennsylvania School of Veterinary Medicine, University of Pittsburgh, University of Quebec, University of Queensland, University of Rennes, University of Rochester, University of Rostock, University of Sheffield, University of Sherbrooke, University of South Alabama (USA) Mitchell Cancer Institute, University of Southampton, University of South Australia, University of South Carolina, University of South Carolina Research Foundation, University of South Florida, University of Technology Sydney, University of Tennessee, University of Texas, University of Texas Health SCience Center at San Antonio, University of Texas Southwestern Medical Center, University of the Witwatersrand, University of Tokyo, University of Torino, University of Toronto, University of Tubingen, University of Turin, University of Utah, University of Verona, University of Virginia, University of Warsaw, University of Washington, University of Wisconsin, University of Wisconsin-Madison, University of Zurich, UPMC, Uppsala University, UroGen Pharma, US Army, US Army Medical Research Institute of Infectious Diseases, US Department of Commerce, US Department of Veteran Affairs, Utah Genome Project, UT Southwestern Medical Center, UW Medicine, Vaccinex, Vaccitech, Valera Pharmaceutical, Validogen, Valitacell, Vall d’Hebron Research Institute, Valo Therapeutics, VA Medical Center (VAMC), Vanderbilt University, Varian Medical Systems, Variant Pharmaceuticals, Vascugen, Vasomune Therapeutics, Vaxeal, Vaximm, VBI Vaccines, Vect-Horus, Vedanta Biosciences, Velabs Therapeutics, VenatoRx, venBio, Venomtech, Ventana Medical Systems, Veracyte, Verastem, Verge Genomics, Verily, Veritas Genetics, Vernalis, Versant Ventures, Verseau Therapeutics, Versiti Blood Research Institute, Vertex Pharmaceuticals, V Foundation for Cancer Research, ViaCyte, Viamet Pharmaceuticals, VIB, Vibalogics, Vical, Victoria University, Viela Bio, View Medical, Vifor Pharma, Vigene Biosciences, ViiV Healthcare, Viking Therapeutics, Vinnova, Viome, ViraCyte, Vir Biotechnology, Virginia Catalyst, Virginia Commonwealth University, Viscient Biosciences, Visionary Pharmaceuticals, VistaGen Therapeutics, Visterra, Vitrisa Therapeutics, Vitro, Vium, Vividion Therapeutics, Vivoryon Therapeutics, VLP Therapeutics, Voyager Therapeutics, Voyant Biotherapeutics, Vtesse, VU Medical Center, VU University Amsterdam, Vycellix, WaferGen Biosystems, Wageningen University, Wake Forest University, Wallace H. 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