Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024

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The Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024 report provides comprehensive understanding and unprecedented access to the discovery stage partnering agreements entered into by the world's leading biopharma companies.

Publication date
August 2024
Number of pages
2,500+
Product type
Research report
Report edition
6
SKU
CP2056

The Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024 report provides a detailed understanding and analysis of how, why and on what terms companies enter discovery stage partnering deals. These deals are discovery stage whereby the licensee obtains a right or an option right to license the licensors product or technology. These deals tend to be multicomponent, starting with collaborative R&D, and commercialization of outcomes.

This report provides details of the latest discovery agreements announced in the healthcare sector.

Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases and databases do not.

This report contains a comprehensive listing of all discovery stage partnering deals announced since 2019 including financial terms where available including over 3,900 links to online deal records of actual discovery partnering deals as disclosed by the deal parties. In addition, where available, records include contract documents as submitted to the Securities Exchange Commission by companies and their partners.

Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.

The initial chapters of this report provide an orientation of discovery stage deal making and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an overview of why companies partner discovery stage compounds/products.

Chapter 3 provides an overview of discovery stage deals strategy and deal structure including numerous case studies. Chapter 4 provides an overview of the various payment strategies used in discovery stage deals.

Chapter 5 provides a review of discovery stage deal making since 2019. Deals activity is reviewed by year, therapeutic area, technology type, as well as most active dealmakers.

Chapter 6 provides a detailed analysis of discovery stage payment terms including headline, upfront, milestone and royalty rates.

Chapter 7 provides a review of the leading discovery stage deal by headline value. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand.

Chapter 8 provides a comprehensive listing of the top 25 most active discovery stage dealmaker companies. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand.

Chapter 9 provides a comprehensive and detailed review of discovery stage partnering deals signed and announced since 2019, where a contract document is available in the public domain.

Chapter 10 provides a comprehensive directory of discovery stage partnering deals since 2019.

The report includes deals announced by hundreds of life science companies including big pharma such as Takeda, AstraZeneca, Eli Lilly, Sanofi, Boehringer Ingelheim, Merck, Roche, Bristol-Myers Squibb, Astellas, Twist Bioscience and many more.

The report also includes numerous tables and figures that illustrate the trends and activities in discovery stage partnering and deal making since 2019.

In addition, a comprehensive appendix of all discovery deals since 2019 is provided organized by partnering company A-Z, deal type, therapy focus and technology type. Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

In conclusion, this report provides everything a prospective dealmaker needs to know about partnering in the research, development and commercialization of discovery stage products and compounds.

Key benefits

Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024 provide the reader with the following key benefits:

  • In-depth understanding of discovery stage deal trends since 2019
  • Access to headline, upfront, milestone and royalty data
  • Analysis of the structure of discovery stage agreements with numerous real life case studies
  • Insight into the terms included in a discovery stage agreement, together with real world clause examples
  • Understand the key deal terms companies have agreed in previous deals
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies


Report scope

Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024 is intended to provide the reader with an in-depth understanding and access to discovery stage deal trends and structure of deals entered into by leading companies worldwide.

Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024 include:

  • Trends in discovery stage dealmaking in the biopharma industry since 2019
  • Analysis of discovery stage deal structure
  • Access to headline, upfront, milestone and royalty data
  • Case studies of real-life discovery stage deals
  • Access to over 2,900 discovery stage deals
  • The leading discovery stage deals by value since 2019
  • Most active discovery stage dealmakers since 2019
  • The leading discovery stage partnering 2019


In Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024, the available contracts are listed by:

  • Company A-Z
  • Headline value
  • Stage of development at signing
  • Deal type
  • Specific therapy target


Each deal title links via Weblink to an online version of the deal record and where available, the contract document, providing easy access to each contract document on demand.

The Global Discovery Stage Partnering Terms and Agreements in Pharma and Biotech 2019-2024 report provides comprehensive access to available deals and contract documents for over 2,900 discovery stage deals. Analyzing actual contract agreements allows assessment of the following:

What are the precise rights granted or optioned?
What is actually granted by the agreement to the partner company?
What exclusivity is granted?
What is the payment structure for the deal?
How are sales and payments audited?
What is the deal term?
How are the key terms of the agreement defined?
How are IPRs handled and owned?
Who is responsible for commercialization?
Who is responsible for development, supply, and manufacture?
How is confidentiality and publication managed?
How are disputes to be resolved?
Under what conditions can the deal be terminated?
What happens when there is a change of ownership?
What sublicensing and subcontracting provisions have been agreed?
Which boilerplate clauses does the company insist upon?
Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
Which jurisdiction does the company insist upon for agreement law?

The Discovery Stage Partnering Terms and Agreements in Pharma and Biotech report provides the reader with the following key benefits:

 

  • In-depth understanding of discovery stage deal trends since 2019
  • Access to headline, upfront, milestone and royalty data
  • Comprehensive access to over 2,900 discovery stage deals together with contract documents if available
  • Detailed access to actual discovery stage deals entered into by the leading 25 big pharma and big biotech companies along with other biopharma companies
  • Analysis of the structure of discovery stage agreements with numerous real life case studies
  • Identify leading discovery stage deals by value since 2019
  • Identify the most active discovery stage dealmakers since 2019
  • Full listing of discovery stage deals by company A-Z, phase of development, deal type, therapy and technology focus
  • Understand the key deal terms companies have agreed in previous deals
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies

Executive Summary

               

Chapter 1 – Introduction

 

Chapter 2 – Why do companies partner at discovery stage?

2.1. Introduction

2.2. The role of discovery stage partnering

2.2.1. In-licensing at discovery stage

2.2.2. Out-licensing at discovery stage

2.3. Difference between discovery, preclinical and clinical stage deals

2.4. Reasons for entering into discovery stage partnering deals

2.4.1. Licensors reasons for entering discovery stage deals

2.4.2. Licensees reasons for entering discovery stage deals

2.5. The future of discovery stage partnering deals

 

Chapter 3 – Discovery stage deal strategies and structure

3.1. Introduction

3.2. At what stage do companies partner?

3.2.1. Partnering early in pharmaceutical/biotech

3.2.1.1. Discovery and preclinical stage partnering case studies

3.2.1.1.a. Case study 1

3.2.1.1.b. Case study 2

3.2.1.1.c. Case study 3

3.2.1.1.d. Case study 4

3.2.2. Partnering later in pharmaceutical/biotech

3.2.2.1. Clinical stage partnering case studies

3.2.2.1.a. Case study 5

3.2.2.1.b. Case study 6

3.2.2.1.c. Case study 7

3.2.2.1.d. Case study 8

3.3. Early and later stage partnering – a risk/cost comparison

3.4. What do companies spend on discovery, preclinical and clinical stage partnering?

3.5. Pure versus multi-component partnering deals

3.6. Pure licensing agreement structure

3.6.1. Example pure licensing agreements

3.6.1.a. Case study 9

3.6.1.b. Case study 10

3.7. Multicomponent discovery stage partnering agreements

3.7.1.a. Example multicomponent early stage clauses

3.7.1.a. Case study 11

3.7.1.b. Case study 12

 

Chapter 4 – Discovery stage partnering payment strategies

4.1. Introduction

4.2. Discovery stage payment strategies

4.3. Payment options

4.3.1. Headline values

4.3.2. Upfront payments

4.3.2.1. Conditionality of upfront payments

4.3.3. Loans

4.3.4. Convertible loans

4.3.5. Equity

4.3.6. R&D funding

4.3.7. Licensing fees

4.3.8. Milestone payments

4.3.9. Royalty payments

4.3.9.1. Issues affecting royalty rates

4.3.9.2. Royalties on combination products

4.3.9.2.a. Case study 13

4.3.9.3. Guaranteed minimum/maximum annual payments

4.3.9.4. Royalty stacking

4.3.9.5. Royalties and supply/purchase contracts

4.3.10. Quids

4.3.11. Option payments

 

Chapter 5 – Trends in discovery stage deal making

5.1. Introduction

5.2. Discovery stage partnering over the years

5.2.1. Attributes of discovery deals

5.3. Discovery stage partnering by deal type

5.4. Discovery stage partnering by disease type

5.5. Partnering by discovery stage technology type

5.6. Discovery stage partnering by most active company, 2019 to 2024

 

Chapter 6 – Payment terms for discovery stage partnering

6.1. Introduction

6.2. Guidelines for discovery stage payment terms

6.2.1. Upfront payments

6.2.2. Milestone payments

6.2.3. Royalty payments

6.3. Discovery stage payment terms – deal data analysis

6.3.1. Public data

6.3.2. Survey data

6.4. Payment terms analysis

6.4.1. Discovery stage headline values

6.4.2. Discovery stage deal upfront payments

6.4.3. Discovery stage deal milestone payments

6.4.4. Discovery stage royalty rates

 

Chapter 7 – Leading discovery stage deals

7.1. Introduction

7.2. Top discovery stage deals by value

 

Chapter 8 – Top 25 most active discovery stage dealmakers

8.1. Introduction

8.2. Top 25 most active discovery stage dealmakers

 

Chapter 9 – Discovery stage partnering contracts directory

9.1. Introduction

9.2. Discovery stage deals with contracts 2019 to 2024

 

Chapter 10 – Discovery stage deal making by development stage

 

10.1. Introduction

10.2. Deals by discovery stage

 

 

Appendices

                                   

Appendix 1 – Discovery stage dealmaking by companies A-Z

Appendix 2 – Discovery stage dealmaking by industry sector

Appendix 3 – Discovery stage dealmaking by stage of development

Appendix 4 – Discovery stage dealmaking by therapy area

Appendix 5 – Discovery stage dealmaking by technology type

 

About Biopharma Research Ltd

 

Current Partnering

Current Agreements

Recent report titles from Current Partnering

 

Table of figures

 

Figure 1: Definition of discovery, preclinical and clinical phases in dealmaking

Figure 3: Components of the pure licensing deal structure

Figure 4: Payment options for discovery stage partnering deals

Figure 5: Issues affecting royalty rates   

Figure 6: Discovery stage partnering frequency 2019 - 2024       

Figure 7: Discovery stage partnering by deal type since 2019     

Figure 8: Discovery stage partnering by disease type since 2019

Figure 9: Discovery stage partnering by technology type since 2019        

Figure 10: Top 25 most active discovery stage dealmakers, 2019 to 2024

Figure 11: Review of median upfront payments for discovery stage deals

Figure 12: Review of median milestone payments for discovery stage deals        

Figure 13: Review of median royalty payments for discovery stage deals 

Figure 14: Discovery stage deals with a headline value  

Figure 15: Discovery stage deals with an upfront value   

Figure 16: Discovery stage deals with a milestone value 

Figure 17: Discovery stage deals with a royalty rate value           

Figure 18: Top discovery stage deals by deal value since 2019   

Figure 19: Most active discovery stage dealmakers 2019 to 2024

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Heptares, SOTIO, Spanios, Spanish National Cancer Research Centre, SparingVision, Spark Therapeutics, Specifica, SpeeDx, Spindle Biotech, SpliceBio, Spring Bank Pharmaceuticals, SpringWorks Therapeutics, Sprint Biosciences, SpyBiotech, SQZ Biotech, SRI International, St. Baldrick's Foundation, St. Jude Children's Research Hospital, Stallargenes, Stallergenes Greer, Standigm, Stand Up To Cancer, Stanford University, Stanford University School of Medicine, Starpharma, STC Biologics, Stem Genomics, Stemline Therapeutics, StemoniX, Stem Pharm, StemSight, Step Pharma, SteroTherapeutics, Stoke Therapeutics, Storm Therapeutics, Strand Therapeutics, STRATIFYER Molecular Pathology, StrideBio, Structural Genomics Consortium, Strykagen, Sud Investments, Sumaya Biotech, Sumitomo Dainippon Pharma, Sumitomo Mitsui Banking Corporation, Sumitovant Biopharma, Sunnybrook Research Institute, Sun Pharma Advanced Research Company, SunRock Biopharma, Sunshine Biopharma, Sun Yat-sen University, Supercell Biotechnology, Surface Oncology, Sutro Biopharma, Suzhou Porton Advanced Solutions, Suzhou Ribo Life Sciences, SwanBio Therapeutics, Swedish Research Council, Syapse, Sybleu, Syena, Sygnature Discovery, Symbasis, Symphogen, Symvivo, Synaffix, Synbal, Synbiotic Health, Syncromune, Synedgen, SynerK, Syngenta, Synlogic, Syntekabio, Synthego, Synthekine, SyntheX, Syracuse Biopharma, Syros Pharmaceuticals, Systems Oncology, T-Cure Bioscience, Tachyon Therapeutics, Taiho, Taisho Pharmaceutical, Takara Bio, Takeda Oncology, Takeda Pharmaceutical, Takeda Ventures, Talem Therapeutics, Tallac Therapeutics, Talus Bioscience, TamRx, Tanabe Research Laboratories, Tantu Therapeutics, TARA Biosystems, Targovax, Taros Chemicals, Tarus Therapeutics, Tavotek Biotherapeutics, Tavros Therapeutics, Taysha Gene Therapies, TB Alliance, TC BioPharm, TCR2 Therapeutics, Tegmine Therapeutics, Teijin, Tella, Telomir Pharmaceuticals, Temple University, Tempus, Ten63 Therapeutics, TeneoBio, TenNor Therapeutics, Tentarix Biotherapeutics, Terran Biosciences, Terray Therapeutics, Terumo Blood and Cell Technologies, Tesis Biosciences, Tessa Therapeutics, Tessera Therapeutics, Tetra Bio-Pharma, Tetragenetics, Tetra Pharm Technologies, Teva Pharmaceutical Industries, Tevard Biosciences, Texas A&M Health Science Center, Texas A&M University, Texas Heart Institute, TFC Therapeutics, TG Therapeutics, The International AIDS Vaccine Initiative, The Medical Research, Infrastructure, and Health Services Fund of the Tel Aviv Medical Center, Themis Bioscience, The New York Stem Cell Foundation, The Parker Institute For Cancer Immunotherapy, Theragen, TheraPanacea, Therapeutic Solutions International, Thermo Fisher Scientific, Theseus Pharmaceuticals, The Silverstein Foundation for Parkinson's, The Technical University Of Munich, ThinkCyte, ThinkingNodeLife, Thoeris, Thorne HealthTech, Thought Leadership & Innovation Foundation, Thylacine Biotherapeutics, Tianjin CanSino Biotechnology, Tianjin University, Tiba Biotech, Titan Pharmaceuticals, TiumBio, T Med, Tmunity Therapeutics, Tokyo Medical and Dental University, Tolo Biotech, TONIX Pharmaceuticals, Toolgen, Toronto Centre for Psychedelic Science, Toronto Innovation Acceleration Partners, Totient, Totus Medicines, Touchlight, Trakcel, TransCelerate BioPharma, TransCode Therapeutics, Transgene, Translate Bio, Translational Genomics Research Institute, TransThera, Traverse Biosciences, Treadwell Therapeutics, TreeFrog Therapeutics, Treventis, TRexBio, Trianni, Trinity College Dublin, Trinomab Biotech, Triumvira Immunologics, TRT Innovations, TrueBinding, Trutino Biosciences, TScan Therapeutics, Tubulis, Tufts University, TuHURA Biopharma, TuHURA Biosciences, TumorGen, TumorGenesis, Turbine, Turn Biotechnologies, Turnstone Biologics, Turn Therapeutics, Twinstrand Therapeutics, Twist Bioscience, twoXAR, Tyris Therapeutics, Ubiquigent, Ubix Therapeutics, UCB, UCL Business, Ultivue, Ultragenyx Pharmaceuticals, Umoja Biopharma, Uni-Bio Science, UniQuest, UniQure, Unison Medicines, United Immunity, Univercells, Univeristy of Durham, Universal Cells, Universite Laval, University College London, University Gottingen, University Health Network, University Hospital Heidelberg, University Hospital Jena, University Libre of Brussels, University Medical Center Groningen, University of Aberdeen, University of Alabama at Birmingham, University of Amsterdam, University of Arizona, University of Barcelona, University of Basel, University of Bath, University of Bonn, University of British Columbia, University of Calgary, University of California, Davis, University of California, San Diego, University of California Berkeley, University of California Irvine, University of California Los Angeles, University of California San Francisco, University of California Santa Barbara, University of Central Florida Research Foundation, University of Chicago, University of Cincinnati, University of Colorado, University of Connecticut, University of Copenhagen, University of Dundee, University of Edinburgh, University of Florida, University of Florida Research Foundation, University of Geneva, University of Georgia, University of Glasgow, University of Hawaii, University of Helsinki, University of Hong Kong, University of Houston, University of Illinois at Chicago, University of Iowa, University of Kiel, University of Lausanne, University of Lethbridge, University of Louisville, University of L’Aquila, University of Manchester, University of Marburg, University of Maryland, University of Maryland Baltimore, University of Maryland School of Medicine, University of Massachusetts, University of Massachusetts Medical School, University of Melbourne, University of Miami, University of Michigan, University of Minnesota, University of Missouri, University of Montreal, University of Nebraska, University of New South Wales, University of North Carolina, University of Oklahoma, University of Oslo, University of Oxford, University of Pennsylvania, University of Pennsylvania School of Veterinary Medicine, University of Pittsburgh, University of Queensland, University of Saskatchewan, University of Sheffield, University of South Australia, University of Southern California, University of Sydney, University of Technology Sydney, University of Texas, University of Texas Health SCience Center at San Antonio, University of Texas Medical Branch, University of Texas Southwestern Medical Center, University of the Witwatersrand, University of Tokyo, University of Toronto, University of Tsukuba, University of Tubingen, University of Vermont, University of Verona, University of Virginia, University of Washington, University of Wisconsin, University of Wisconsin-Madison, University of Wollongong, University of Wurzburg, University of Zurich, Unravel Biosciences, Unum Therapeutics, Upadia, Uppsala University, Uppthera, UroGen Pharma, USANA Health Science, US Army Medical Research and Material Command, US Army Medical Research Institute of Chemical Defense, US Army Medical Research Institute of Infectious Diseases, US Government, Usynova Pharmaceuticals, Utrecht University, UWM Research Foundation, Vaccinex, Vaccitech, Valence Discovery, Valitacell, Vall d’Hebron Research Institute, Valo Health, Valo Therapeutics, Van Andel Institute, Vanda Pharmaceuticals, Vanderbilt University, VantAI, Variant Pharmaceuticals, Variational AI, Vaxalto Biotherapeutics, VaxEquity, Vaxil BioTherapeutics, Vaximm, VaxThera, Vaxxinity, VBI Vaccines, Vect-Horus, VectorY Therapeutics, Velabs Therapeutics, VenatoRx, Veneno Technologies, Venturis Therapeutics, Ventus Therapeutics, Veracyte, Verana Health, Veranome Biosystems, Verantos, Verastem, Veraxa Biotech, Verge Genomics, Verily, VerImmune, Verismo Therapeutics, Vernalis, Versatope Therapeutics, Verseau Therapeutics, Vertex Pharmaceuticals, Verve Therapeutics, Vetigenics, Vetophage, VIB, Vibliome Therapeutics, Victoria University, Viewpoint Molecular Targeting, Vifor Pharma, ViGeneron, ViiV Healthcare, Vincere Biosciences, Vinnova, Viome, Vipergen, Viravaxx, Vir Biotechnology, Virginia Commonwealth University, Virginia Polytechnic Institute and State University, Virion Therapeutics, Virogen, Vittoria Biotherapeutics, Vituity, Viva Biotech, Vividion Therapeutics, Vivlion, vivoPharm, Vivoryon Therapeutics, Vivtex, Volastra Therapeutics, Voltron Therapeutics, Vor Biopharma, Voronoi, Voyager Therapeutics, Vuja De Sciences, Vyant Bio, Vycellix, VYNE Therapeutics, Wageningen University, Wake Forest Institute for Regenerative Medicine, Wake Forest University, Walking Fish Therapeutics, Washington University in St Louis, WaVe Lifesciences, WAVE Life Sciences, Weatherden, Weizmann Institute, Wellcome Trust Sanger Institute, Wellmarker Bio, Western Digital, Westlake Pharma, Whitehead Institute, WhiteLab Genomics, Willow Biosciences, WindMIL Therapeutics, WinterLight Labs, Wisconsin Alumni Research Foundation, Wiseman Cancer Research Foundation, Wistar Institute, Wonkwang University, Wren Therapeutics, WUGEN, WuXi Biologics, WuXi XDC, Wyss Institute, X-chem, xCella Biosciences, Xcell Biosciences, Xcellomics, Xencor, Xenetic Biosciences, Xilio Therapeutics, Xilis, Ximbio, Xlife Sciences, Xoma, XtalPi, Xylyx Bio, Xyphos Biosciences, Y-Biologics, Y-Trap, Yale University, YASKAWA Electric, Yatiri Bio, Yeda Research and Development Company, Yissum Research Development, Yiviva, Ymir Genomics, Ymmunobio, Yufan Biotechnologies, Yuhan Corporation, YUMAB, Yumanity Therapeutics, ZabBio, ZAI Laboratory, Zealand Pharma, ZebiAI Therapeutics, ZeClinics, Zelluna Immunotherapy, Zentalis Pharmaceuticals, Zenyaku Kogyo, Zephyr AI, Zhejiang Doer Biotechnology, Ziopharm Oncology, Zoetis, Zogenix, ZS Pharma, Zydus Cadila, Zymeworks, ZYUS Life Sciences

Current Partnering reports provide insight into the trends and terms of partnering deals in the global life sciences sector.

Current Partnering reports are updated every six months to ensure the user has access to the latest announcements and trends in the topic focus of the report.

Current Partnering analysts review the deal data to provide an overview and analysis of deal trends, including example deals and terms.

Current Partnering reports source deal data from our proprietary deals and alliances database, Current Agreements. The database is updated daily by our analysts with new deals as they are announced globally by the company’s party to the deal. In addition, deal records are updated with new data as it becomes available.

The data in the Current Agreements deals and alliances database is obtained from secondary sources such as publicly available industry sources including press releases, company presentations, investor presentations, company SEC filings, other company filings, company websites, conference presentations. Sources are identified to allow for user verification.

Current Partnering provides comprehensive coverage of the following partnering or deal types:
• Asset purchase
• Assignment
• Co-development
• Co-market
• Co-promotion
• Collaborative R&D
• Contract service
• CRADA
• Cross-licensing
• Development
• Distribution
• Equity purchase
• Evaluation
• Grant
• Joint venture
• Licensing
• Loan
• Manufacturing
• Marketing
• Option
• Promotion
• Research
• Royalty financing
• Settlement
• Spin out
• Sub license
• Supply
• Termination
• Warrant

Every deal record is fully categorized and includes the following data, where available:
• Industry sector
• Therapy areas
• Technology type
• Deal components
• Financial terms
• Stage of development
• Exclusivity
• Asset type
• Geographic focus
• Excluded geography
• Company press release
• SEC filing data including contract document

All financial amounts are converted to US$ using the exchange rate available on the date of deal announcement, enabling direct comparison of deal terms across international territories.

Financial data and contract documents displayed in deal records is obtained from public sources, where disclosed by the parties to the deal.

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