Global Option and Evaluation Deals in Pharma, Biotech and Diagnostics 2014-2020


The Global Option and Evaluation Deals in Pharma, Biotech and Diagnostics 2014-2020 report provides comprehensive understanding and unprecedented access to the option and evaluation partnering agreements entered into by the worlds leading biopharma companies.

Publication date
April 2020
Number of pages
Product type
Research report
Available formats
PDF document
Report edition

The Global Option and Evaluation Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 report.


This report provides details of the latest option and evaluation agreements announced in the pharmaceutical, biotechnology and diagnostic sectors. Fully revised and updated, the report provides details of option and evaluation agreements from 2014 to 2020.


There are two major forms of deal term that allow a party to a deal to secure rights to an asset subject to a future event namely, option and evaluation.


Evaluation agreements allow a party to the deal to obtain rights to a technology or compound, subject to a period of time to evaluate the quality, scope and applicability of the technology to its intended endpoint.Normally the technology is at an early stage and/or unproven and the partnering companywishes to assess the technology as part of the due diligence process in advance of signing a long term licensing agreement.


Evaluation agreements have been a mainstay of technology licensing from the earliest days.


An option agreement differs in that the option is often an integral part of an agreement already entered by the parties, providing the party with the option right to retain or extend certain rights to the technology already partnered.


Option agreements are becoming increasingly popular as they create additional flexibility within a deal for additional rights that the parties do notwish to commit at the outset of the agreement.


This report focuses on option and evaluation agreements and clauses within broader agreements between big pharma-big pharma, big pharma – smaller company, and smaller company-smaller company, providing a detailed insight into all such deals.


The report provides a detailed understanding and analysis of how and why companies enter option and evaluation deals. The majority of deals are multicomponent whereby the licensor retains either a option and evaluation right to the resultant product of the research collaboration. There are also numerous pure option and evaluation deals whereby the products originator takes on a partner in order to advance the product or compound to a point where the licensee might seek to proceed to a licensing deal.


Understanding the flexibility of a prospective partner’s negotiated deals terms provides critical insight into the negotiation process in terms of what you can expect to achieve during the negotiation of terms. Whilst many smaller companies will be seeking details of the payments clauses, the devil is in the detail in terms of how payments are triggered – contract documents provide this insight where press releases and databases do not.


This report contains a comprehensive listing of all option and evaluation deals announced since 2014 as recorded in the Current Agreements deals and alliances database, including financial terms where available, plus links to online copies of actual option and evaluation contract documents as submitted to the Securities Exchange Commission by companies and their partners.


Contract documents provide the answers to numerous questions about a prospective partner’s flexibility on a wide range of important issues, many of which will have a significant impact on each party’s ability to derive value from the deal.


The initial chapters of this report provide an orientation of option and evaluation dealmaking and business activities. Chapter 1 provides an introduction to the report, whilst chapter 2 provides an analysis of the trends in option and evaluation as well as a discussion on the merits of the type of deal.


Chapter 3 provides an overview of the structure of option and evaluation deals. The chapter includes numerous case studies to enable understanding of both pure option and evaluation deals and multicomponent deals where option and evaluation forms a part.


Chapter 4 provides a review of the leading option and evaluation deals since 2014. Deals are listed by headline value, signed by big pharma and big biotech and most active of all biopharma companies. Where the deal has an agreement contract published at the SEC a link provides online access to the contract via the Current Agreements deals and alliances database.


Chapter 5 provides a comprehensive listing of the top 25 most active option and evaluation dealmaker companies. Each deal title links via Current Agreements deals and alliances database to an online version of the full deal record, and where available, the actual contract document, providing easy access to each deal record on demand. 


Chapter 6 provides a comprehensive and detailed review of option and evaluation deals signed and announced since 2014 where a contract document is available. Contract documents provide an indepth insight into the actual deal terms agreed between the parties with respect to the option and evaluation deal.


In addition the report includes a series of appendices containing a comprehensive listing of all option and evaluation deals announced since 2014.


Each listing is organized as an appendix by company A-Z, stage of development at signing, and therapeutic area. Each deal title links via hyperlink to an online version of the deal record including, where available, the actual contract document.


The report includes deals announced by hundreds of life science companies including big pharma such as Abbott, Abbvie, Actavis, Amgen, Astellas, AstraZeneca, Baxter, Bayer, Biogen Idec, BMS, Celgene, Eisai, Eli Lilly, Gilead, GSK, J&J, Kyowa Hakko, Merck, Mitsubishi, Mylan, Novartis, Pfizer, Roche, Sanofi, Shire, Takeda, Teva, and Valeant, amongst many others.


The report also includes numerous tables and figures that illustrate the trends and activities in option and evaluation dealmaking since 2014.


In conclusion, this report provides everything a prospective dealmaker needs to know about option and evaluation alliances.


Key benefits


Global Option and Evaluation Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 provides the reader with the following key benefits:


  • In-depth understanding of option and evaluation deal trends since 2014
  • Analysis of the structure of option and evaluation agreements with numerous real life case studies
  • Comprehensive access to actual option and evaluation deals entered into by the world’s biopharma companies
  • Detailed access to actual option and evaluation contracts enter into by the leading twenty five big pharma companies
  • Insight into the terms included in a option and evaluation agreement, together with real world clause examples
  • Understand the key deal terms companies have agreed in previous deals           
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies


Report scope


Global Option and Evaluation Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 is intended to provide the reader with an in-depth understanding of the option and evaluation trends and structure of deals entered into by leading biopharma companies worldwide.


Global Option and Evaluation Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 includes:


  • Trends in option and evaluation dealmaking in the biopharma industry since 2014
  • Analysis of option and evaluation deal structure
  • Case studies of real-life option and evaluation deals
  • Access to option and evaluation deal records
  • The leading option and evaluation deals by value since 2014
  • Most active option and evaluation dealmakers since 2014
  • The leading option and evaluation partnering resources


In Global Option and Evaluation Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020, the available deals are listed by:


  • Company A-Z
  • Headline value
  • Stage of development at signing
  • Therapeutic area
  • Technology type


Each deal title links via Weblink to an online version of the actual deal record, providing easy access to each contract document where available.


The Global Option and Evaluation Partnering Terms and Agreements in Pharma, Biotech and Diagnostics 2014-2020 report provides comprehensive access to available records for option and evaluation deals, including contract documents where available. Analyzing actual contract agreements allows assessment of the following:


  • What are the precise rights granted or optioned?
  • What is actually granted by the agreement to the partner company?
  • What exclusivity is granted?
  • What is the payment structure for the deal?
  • How are sales and payments audited?
  • What is the deal term?
  • How are the key terms of the agreement defined?
  • How are IPRs handled and owned?
  • Who is responsible for commercialization?
  • Who is responsible for development, supply, and manufacture?
  • How is confidentiality and publication managed?
  • How are disputes to be resolved?
  • Under what conditions can the deal be terminated?
  • What happens when there is a change of ownership?
  • What sublicensing and subcontracting provisions have been agreed?
  • Which boilerplate clauses does the company insist upon?
  • Which boilerplate clauses appear to differ from partner to partner or deal type to deal type?
  • Which jurisdiction does the company insist upon for agreement law?

Global Option and Evaluation Deals in Pharma, Biotech and Diagnostics 2014-2020 provides the reader with the following key benefits:


  • In-depth understanding of option and evaluation partnering deal trends since 2014
  • Insight into the terms included in an option and evaluation agreement, together with real world clause examples
  • Identify leading option and evaluation  deals by value since 2014
  • Identify the most active option and evaluation dealmakers since 2014
  • Analysis of key deal financials including headline value, upfront, milestone payments and royalty rates
  • Full listing of option and evaluation deals by company A-Z, deal value, phase of development, deal type, therapy and technology focus
  • Comprehensive access to option and evaluation deals entered into by the world’s biopharma companies, together with contract documents if available
  • Understand the key deal terms companies have agreed in previous deals
  • Undertake due diligence to assess suitability of your proposed deal terms for partner companies

Executive Summary


Chapter 1 – Introduction


Chapter 2 – Trends in option and evaluation dealmaking


2.1. Introduction

2.2. Difference between option and evaluation deals

2.2.1. Types of option agreement

2.3. Trends in option and evaluation deals since 2014

2.3.1. Option and evaluation dealmaking by year since 2014

2.3.2. Option and evaluation dealmaking by phase of development since 2014

2.3.3. Option and evaluation dealmaking by industry sector since 2014

2.3.4. Option and evaluation dealmaking by therapy area since 2014

2.3.5. Option and evaluation dealmaking by technology type since 2014

2.3.6. Option and evaluation dealmaking by most active company since 2014

2.4. Option-based deals

2.4.1. Attributes of option-based deals

2.4.2. Reasons for entering an option-based deal

2.4.3. Uptake of option exercise

2.4.4.The future of option-based deals

2.5. Co-promotion options

2.5.1. Attributes of co-promotion in multi-component deals

2.5.2. Reasons for including co-promotion options in a deal

2.5.3. Uptake of co-promotion rights

2.5.4. Co-promotion rights as bargaining chips

2.5.5. The future of co-promotion as part of multicomponent deals

2.6. Company acquisition options

2.6.1. Case study 1: Cephalon – Ception

2.6.2. Case study 2: Endo – Indevus

2.6.3. The future of option to acquire deals


Chapter 3 – Overview of option and evaluation deal structure 


3.1. Introduction

3.2. Option and evaluation agreement structure

3.2. Example evaluation agreements

3.2.1.a. Case study 3: Idenix Pharmaceuticals – Janssen Pharmaceuticals

3.3. Option agreement structure

3.3.1. Example option agreements

3.3.1.a. Option to license

Case study 4: Biogen Idec – Isis Pharmaceuticals

3.3.1.b. Option to extend/expand applications/territories

Case study 5: Novartis –Prometheus

3.3.1.c. Option to finance

Case study 6: Amarantus BioSciences– Power3 Medical Products

3.3.1.d. Option to co-promote

Case study 7: Teva – OncoGenex Pharmaceuticals

3.3.1.e. Option to manufacture/supply

Case study 8: NPS Allelix – Nycomed

3.4. Option to acquire agreement structure

3.4.1. Example acquisition option clauses

3.4.1.a. Case study 9: ViroPharma– Meritage Pharma

3.4.1.b. Case study 10: Nuvasive – Progentix Orthobiology


Chapter 4 – Leading option and evaluation deals


4.1. Introduction

4.2. Top option and evaluation deals by value


Chapter 5 – Top 25 most active option and evaluation dealmakers


5.1. Introduction

5.2. Top 25 most active option and evaluation dealmakers


Chapter 6 – Option and evaluation contracts directory


6.1. Introduction

6.2. Option andevaluation deals with contracts since 2014




Appendix 1 – Option and evaluation dealmaking by companies A-Z

Appendix 2 – Option and evaluation dealmaking by industry sector

Appendix 3 – Option and evaluation dealmaking by stage of development

Appendix 4 – Option and evaluation dealmaking by therapy area

Appendix 5 – Option and evaluation dealmaking by technology type


About Wildwood Ventures


Current Partnering

Current Agreements

Recent report titles from CurrentPartnering




Figure 1: Definition of option and evaluation deals

Figure 2: Types of option right

Figure 3: Trends in option and evaluation deal announcements since 2014

Figure 4: Option and evaluation deals signed at each phase of development since 2014

Figure 5: Option and evaluation deals by industry sector since 2014

Figure 6: Option and evaluation deals by therapy area since 2014

Figure 7: Option and evaluation deals by technology type since 2014

Figure 8: Top 25 most active option and evaluation dealmakers since 2014

Figure 9: Example deals where co-promotion options have been actively exercised since 2014

Figure 10: Recent ‘option to acquire’ deals

Figure 11: Components of the option and evaluation deal structure

Figure 12: Types of option in an agreement

Figure 13: Attributes of option terms

Figure 14: Top option and evaluation deals by value since 2014

Figure 15: Most active option and evaluation dealmakers since 2014

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Diseases, National Comprehensive Cancer Network (NCCN), National Eye Institute, National Heart, Lung and Blood Institute, National Institute of Allergy and Infectious Diseases, National Institute of Neurological Disorders and Stroke, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institute on Drug Abuse (NIDA), National Institutes of Health, National Institutes of Health Center for Regenerative Medicine, Nationwide Children’s Hospital, Navidea Biopharmaceuticals, NBE Therapeutics, NEC, Nektar Therapeutics, Nemucore Medical Innovations, NeoImmuneTech, Neomed Institute, Neon Therapeutics, Neovacs, Nestle Health Science, Netherlands Cancer Institute, NeuMoDx Molecular, Neurocrine Biosciences, NeuroSigma, NeuroVive Pharmaceutical, Nevada Center For Behavioral Health, New England Research Institutes, Newlink Genetics, New York State, NextCure, Nextera, NGM Biopharmaceuticals, Nicox, Nihon Medi-Physics, Nimbus Therapeutics, Nodality, Noile-Immune Biotech, Nordic 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PDC*line Pharma, PEAR Therapeutics, PellePharm, Pepsico, PeptiDream, PeptiMimesis, PerkinElmer, Pfenex, Pfizer, Pharmacyclics, PharmaIN, PharmaJet, Pharmatech, Pharming Group, Pherin Pharmaceuticals, Philogen, Phio Pharmaceuticals, PhoreMost, Phosplatin Therapeutics, Phylogica, PhysIQ, PhytoTech Medical, Pieris, Pierre Fabre, Piqur Therapeutics, Plant Bioscience Limited, Potenza Therapeutics, Precision BioSciences, Premune, Prevail Therapeutics, PreveCeutical Medical, Prime Therapeutics, ProBioGen, Pronutria, Protagonist Therapeutics, Protein Sciences, Proteomics International, Prothelia, Prothena Biosciences, pSivida, Pulmatrix, Pulmonox, Purdue Pharma, Puregraft, Puridify, PvP Biologics, Q BioMed, Qiagen, QT Vascular, Quad Technologies, Quark Venture, Quartet Medicine, Quebec Consortium for Drug Discovery, Queensland Institute of Medical Research (QIMR), Quotient Clinical, Rafael Pharmaceuticals, Rani Therapeutics, Rappaport Research Institute, Raptor Pharmaceutical, Recursion Pharmaceuticals, RedHill Biopharma, Regeneron Pharmaceuticals, Regenerx, Regenesys, Regenxbio, Regulus Therapeutics, RenalytixAI, Reproductive Medicine Associates of New York, Resolution Bioscience, Respicardia, RESprotect, Resverlogix, Retrophin, rEVO Biologics, Revolution Medicines, Rexahn Pharmaceuticals, Rheos Medicines, Ribometrix, Robert H. Lurie Comprehensive Cancer Center, Roche, Rocket Pharmaceuticals, Rockwell Medical, Rodin Therapeutics, Rohto Pharmaceutical, Roivant Sciences, Romer Labs, Rosetta Genomics, Roswell Park Cancer Institute, Rugen Therapeutics, Rumpus Therapeutics, RXi Pharmaceuticals, SAB Biotherapeutics, Salix Pharmaceuticals, Salud Digna, SAMIL Pharm, Samsung Bioepis, Samyang Biopharmaceuticals, Sandoz, Sangamo BioSciences, San Martino Hospital, Sanofi, Sanofi-Aventis, Sanofi-Pasteur, San Raffaele Scientific Institute, San Raffaele Telethon Institute for Gene Therapy, Santaris Pharma, Santen Pharmaceutical, Santhera Pharmaceuticals, Sarepta Therapeutics, Scholar Rock, Schrodinger, ScreenCell, Scripps Research Institute, Scripps Translational Science Institute, Seattle Genetics, Selecta Biosciences, SemaThera, Senexta, Senju Pharmaceutical, Senomyx, Sensorion, Sentinel Oncology, Sequenom, Seres Therapeutics, Serum Institute of India, Seven and Eight Biopharmaceuticals, Sevion Therapeutics, Shattuck Labs, Shenzhen Chipscreen Biosciences, Shenzhen Hepalink Pharmaceutical, Shin Nippon Biomedical Laboratories, Shionogi, Shire Pharmaceuticals, Siamab Therapeutics, Siemens, Signet International, Signet Medical Solutions, Singapore Immunology Network, Singapore Institute of Advanced Medicine, SiO2 Medical Products, Sirenas, Sirona Genomics, SkyePharma, Skyhawk Therapeutics, Small Business Innovation Research, Societatea Nationala Nuclearelectrica, SolaranRx, Sorin Group, Sorrento Therapeutics, Sosei, SOTIO, Spark Therapeutics, Specialised Therapeutics, Spectral Medical, Spero Therapeutics, Spherix, Sphingotec, SpineThera, Spring Bank Pharmaceuticals, SpringWorks Therapeutics, Squalan Natural Health, St. Jude Children's Research Hospital, Stahl, Stallargenes, Stanford University, Starpharma, Staten Biotechnology, STC.UNM, Stealth Therapeutics, St George Street Capital, Strategic Science and Technologies, StrideBio, Sucampo Pharmaceuticals, Sumitovant Biopharma, Summit Therapeutics, SurePure, Surface Oncology, Sutro Biopharma, Suzhou NeuPharma, Swedish Orphan Biovitrum, Symphogen, Synaffix, Syndax Pharmaceuticals, Synlogic, Synthetic Genomics, Syros Pharmaceuticals, Taiho, Taiwan Liposome Company, Takeda Pharmaceutical, Takeda Ventures, Talix Therapeutics, Tamarack Biotics, Tango Therapeutics, TapImmune, Targacept, Targovax, Taxus Cardium Pharmaceuticals, Techcomp, Technology University Dresden, Teijin, Tekmira Pharmaceuticals, Tel Aviv University, Teleflex, Telix Pharmaceuticals, Temple University, TeneoBio, TeneoOne, Terumo BCT, Tesaro, Tetra Bio-Pharma, Tetra Discovery Partners, Tetragenetics, Teva Pharmaceutical Industries, The Parker Institute For Cancer Immunotherapy, Theragnostics, Therapeia, Therapix Bio, Theravance, Thomas Jefferson University, TiGenix, Titan Pharmaceuticals, Tiziana Life Sciences, Tizona Therapeutics, T Med, Todos Medical, Torque Therapeutics, TRACON Pharmaceuticals, TransBio, Transgene, Transgenomic, Transition Therapeutics, Transparency Life Sciences, Trefoil Therapeutics, Triphase Accelerator, TriReme Medical, Trizell, True North Laboratory, Tsinghua University, Tubulis, Tufts Medical Center, Tufts University, Turnstone Biologics, TxCell, Tyme Technologies, Ubiquigent, UbiVac, Ultragenyx Pharmaceuticals, UMN Pharma, Unilife, UniQuest, Universite catholique de Louvain, Universite Laval, University College London, University Medical Center Groningen, University Medical Center Hamburg-Eppendorf, University of Bonn, University of California Los Angeles, University of California San Francisco, University of Chicago, University of Cincinnati, University of Colorado, University of Connecticut, University of Florida, University of Florida Research Foundation, University of Guelph, University of Illinois at Chicago, University of Kentucky, University of Leipzig, University of Maryland Baltimore, University of Maryland Ventures, University of Massachusetts, University of Massachusetts, Amherst, University of Massachusetts Medical School, University of Miami, University of Minnesota, University of Montreal, University of Nevada, University of New Mexico, University of Oxford, University of Pennsylvania, University of Pittsburgh, University of Rochester, University of Sydney, University of Texas Southwestern Medical Center, University of Toronto, University of Washington, University of Wisconsin, UroGen Pharma, Urovant Sciences, US Army, US Army Medical Research Institute of Chemical Defense, US Army Medical Research Institute of Infectious Diseases, US Department of Veteran Affairs, US Veterans Administration, Vaccinex, Valens GroWorks, Valneva, Vantage Health, Vasomune Therapeutics, Vaxart, Vaximm, VDM Biochemicals, Vect-Horus, Vectura, Vedanta Biosciences, Velo Bio, Ventana Medical Systems, VentiRx Pharmaceuticals, Verastem, Versant Ventures, Vertex Pharmaceuticals, ViaCyte, Vifor-Fresenius Medical Care Renal Pharma Ltd, Vifor Pharma, Vinnova, Virax, Vir Biotechnology, Viroclinics Biosciences, VistaGen Therapeutics, Visterra, Vitae Pharmaceuticals, Vitaeris, VitalConnect, Vital Therapies, Vitrisa Therapeutics, Vivaldi Biosciences, Vivet Therapeutics, Vivione Biosciences, Vivior, Vivoryon Therapeutics, Vivus, Volpara Solutions, Voluntis, Voyager Therapeutics, Vyriad, Washington University in St Louis, WAVE Life Sciences, Weill Cornell Medical College, Western Oncolytics, WinterLight Labs, Wistar Institute, Women & Infants Hospital of Rhode Island, Worldwide Clinical Trials, X-chem, Xencor, Xenon Pharmaceuticals, XERIS Pharmaceuticals, Xoma, Yale University, Yeda Research and Development Company, Yissum Research Development, Yonsei University Severance Hospital, YouHealth Eyetech, ZAI Laboratory, ZappRx, Zealand Pharma, Ziopharm Oncology, Zoetis, Zomedica, Zymeworks